N/A
N=23
Effects of Reducing Indoor Air Pollution on the Adult Asthmatic Response
Asthma
Bottom Line
View on ClinicalTrials.gov: NCT02153359 ↗Enrolled (actual)
23
Serious AEs
0.0%
Results posted
Sep 2019
Primary outcome: Primary: PM2.5 Concentration (ug/m^3) — 18.95; 32.73 ug/m^3
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- High Efficiency Particulate Air Cleaner (Device); Sham air cleaner (Device)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Johns Hopkins University
- Primary completion
- Sep 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY PM2.5 Concentration (ug/m^3) |
18.95; 32.73 | — |
| PRIMARY PM2.5-10 Concentration (ug/m^3) |
7.89; 13.93 | — |
| SECONDARY Number of Symptom-free Days |
4; 3.76 | — |
| SECONDARY Number of Days With Activity Limitations |
2.48; 2.33 | — |
| SECONDARY Number of Nights Disrupted by Asthma Symptoms |
0.95; 1.14 | — |
| SECONDARY Number of Days of School/Work Missed Due to Asthma Symptoms |
0.10; 0.24 | — |
| SECONDARY Number of Days of Unscheduled Visits to the Doctor Due to Asthma Symptoms |
0.19; 0.14 | — |
| SECONDARY Asthma Disease Status as Assessed by the Asthma Control and Communication Instrument (ACCI) |
2.44; 2.50 | — |
| SECONDARY Asthma-specific Health-related Quality of Life as Assessed by the Asthma Quality of Life Questionnaire (AQLQ) |
6.15; 6.06 | — |
| SECONDARY Air Nicotine Concentration (ug/m^3) |
0.37; 0.37 | — |
| SECONDARY Bronchoalveolar Lavage Differential Neutrophil Count |
1.49; 2.10 | — |
| SECONDARY Bronchoalveolar Lavage Differential Eosinophil Count |
0.26; 0.45 | — |
| SECONDARY Pre-bronchodilator Forced Vital Capacity (Litres) |
3.43; 3.52 | — |
| SECONDARY Pre-bronchodilator Forced Expiratory Volume in 1 Second (Litres) |
2.55; 2.60 | — |
| SECONDARY FEV1 Percentage of FVC |
0.75; 0.75 | — |
Summary
This study is about asthma and how the environment affects asthma. Scientists know that air pollution (such as cigarette smoke and other particles in the air) can make asthma symptoms worse. This research is being done to study how the health of a person with asthma responds to an air cleaner. The investigator hypothesize that an air cleaner will improve the health of persons with asthma.
Eligibility Criteria
Inclusion Criteria
- Age 18-50 years of age
- Non-smoker ( = 6 months within Baltimore
- Enrollment in, and completion of, the observational environmental asthma study "Inhale 1"
Exclusion Criteria
- Current diagnosis of another major pulmonary disease, other significant morbidity
- Pregnancy (as defined by a positive urine pregnancy test at screening of all women of child-bearing potential)
- Planning to relocate residence or activity that necessitates travel away from home for prolonged period of time during the study period
- Current use of an air cleaner in the home
Data sourced from ClinicalTrials.gov (NCT02153359). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.