N/A
N=112
Dose Response of Ketorolac in Knee Arthroscopy
Meniscectomy
Bottom Line
View on ClinicalTrials.gov: NCT02181426 ↗Enrolled (actual)
112
Serious AEs
0.0%
Results posted
Jun 2018
Primary outcome: Primary: PACU Opiate Consumption — 7.7; 6.3; 6.5; 5.0 IV Morphine Equivalents (mg)
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Ketorolac Dose (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Medical University of South Carolina
- Primary completion
- Dec 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY PACU Opiate Consumption |
7.7; 6.3; 6.5; 5.0 | — |
Summary
Ketorolac is administered as current practice to the majority of patients undergoing knee arthroscopy, the appropriate dose of ketorolac to be administered has not been evaluated.
Eligibility Criteria
Population: Patients scheduled for outpatient knee arthroscopy under general anesthesia with ASA physical status I-III ages 18-65 years old. All subjects will receive informed consent. Subjects will not be eligible to participate if they cannot provide informed consent. Non-English speaking patients will not be included due to the limited time and availability of translators.
Inclusion Criteria
- Ability to consent and desire to participate in study
- Outpatient knee arthroscopy with Dr. C. David Geier
- ASA physical status I-III
- 18-65 years old
- Over 50 kg (110 pounds)
- General anesthesia
Exclusion Criteria
- Any contraindication to receiving a non-steroidal antiinflammatory medication (including but not limited to allergy to any non-steroidal antiinflammatory medications including aspirin; chronic renal insufficiency; history of gastric ulcers, gastritis, peptic ulcers or gastrointestinal bleeding; severe volume depletion; presence of cerebrovascular bleeding or high risk of bleeding)
- Allergy to propofol, fentanyl or hydromorphone.
- Any chronic painful conditions requiring opioid use for over the last 6 months
- Emergency surgery
- Altered mental status (not oriented to place, person or time)
- Pregnant or lactating patients
- Patient is taking non-steroidal antiinflammatory medications (including aspirin)1 at home and took that medication on day of surgery.
- Non-English speaking
- Patient refusal to study
- Patient refusal or not a candidate for general anesthesia with Laryngeal Mask Airway (LMA)
Data sourced from ClinicalTrials.gov (NCT02181426). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.