N/A
Completed N=112
Dose Response of Ketorolac in Knee Arthroscopy
Meniscectomy
Source: ClinicalTrials.gov NCT02181426 ↗
Enrolled (actual)
112
Serious AEs
0.0%
Results posted
Jun 2018
Primary outcomePrimary: PACU Opiate Consumption — 7.7; 6.3; 6.5; 5.0 IV Morphine Equivalents (mg)
Summary
Ketorolac is administered as current practice to the majority of patients undergoing knee arthroscopy, the appropriate dose of ketorolac to be administered has not been evaluated.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY PACU Opiate Consumption |
7.7; 6.3; 6.5; 5.0 | — |
Eligibility Criteria
Population: Patients scheduled for outpatient knee arthroscopy under general anesthesia with ASA physical status I-III ages 18-65 years old. All subjects will receive informed consent. Subjects will not be eligible to participate if they cannot provide informed consent. Non-English speaking patients will not be included due to the limited time and availability of translators.
Inclusion Criteria
- Ability to consent and desire to participate in study
- Outpatient knee arthroscopy with Dr. C. David Geier
- ASA physical status I-III
- 18-65 years old
- Over 50 kg (110 pounds)
- General anesthesia
Exclusion Criteria
- Any contraindication to receiving a non-steroidal antiinflammatory medication (including but not limited to allergy to any non-steroidal antiinflammatory medications including aspirin; chronic renal insufficiency; history of gastric ulcers, gastritis, peptic ulcers or gastrointestinal bleeding; severe volume depletion; presence of cerebrovascular bleeding or high risk of bleeding)
- Allergy to propofol, fentanyl or hydromorphone.
- Any chronic painful conditions requiring opioid use for over the last 6 months
- Emergency surgery
- Altered mental status (not oriented to place, person or time)
- Pregnant or lactating patients
- Patient is taking non-steroidal antiinflammatory medications (including aspirin)1 at home and took that medication on day of surgery.
- Non-English speaking
- Patient refusal to study
- Patient refusal or not a candidate for general anesthesia with Laryngeal Mask Airway (LMA)
Data sourced from ClinicalTrials.gov (NCT02181426). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.