Phase 4
N=61
Effects of Deep Neuromuscular Blockade on Intraoperative Respiratory Mechanics
Laparoscopic Renal Surgery · Laparoscopy · Muscle Relaxation
Bottom Line
View on ClinicalTrials.gov: NCT02185339 ↗Enrolled (actual)
61
Serious AEs
0.0%
Results posted
Jun 2016
Primary outcome: Primary: Thoracopulmonary Compliance — 51.9; 52.3; 34.6; 31.9 ml/cmH2O
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Rocuronium (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Seoul St. Mary's Hospital
- Primary completion
- Jan 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Thoracopulmonary Compliance |
51.9; 52.3; 34.6; 31.9; 33.6; 30.8 | — |
| SECONDARY Arterial Oxygen Tension/Inspired Oxygen Fraction |
477; 483; 467; 461; 468; 465 | — |
| SECONDARY Arterial to End-tidal Partial Pressure of Carbon Dioxide Difference |
4.3; 4.3; 5.8; 7.1; 5.8; 7.2 | — |
| SECONDARY Estimated Dead Space |
11.8; 11.9; 14.1; 16.5; 14.1; 16.4 | — |
| SECONDARY Pulmonary Shunt |
13.2; 12.4; 12.7; 13.2; 15.0; 14.8 | — |
Summary
The primary objective of the current study is to compare intraoperative respiratory mechanics in patients receiving laparoscopic renal surgery under deep neuromuscular blockade (dNMB) and under moderate neuromuscular blockade (mNMB). In addition, we will compare intraoperative hemodynamics and postoperative pulmonary function between the two groups.
Eligibility Criteria
Inclusion Criteria
- ASA I or II patients scheduled to undergo laparoscopic renal surgery
Exclusion Criteria
- BMI ≥35 kg/m2
- Known neuromuscular disease
- History of chronic obstructive pulmonary disease
- Asthma
- Pneumothorax
- Bronchopleural fistula
- Previous lung surgery
- Previous retroperitoneal surgery
- Hemodynamic instability
- History of cardiopulmonary disease
- Renal insufficiency
Data sourced from ClinicalTrials.gov (NCT02185339). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.