Phase 3
Completed N=47
Vitamin D in Preschoolers With Viral-induced Asthma
Source: ClinicalTrials.gov NCT02197702 ↗Enrolled (actual)
47
Serious AEs
2.1%
Results posted
Dec 2024
Primary outcomePrimary: Change From Baseline in Serum 25OHD — 4.3; 9.6 nmol/L
◆ Published Evidence
Established
49citations · ~7 / year
Impact of two oral doses of 100,000 IU of vitamin D<sub>3</sub> in preschoolers with viral-induced asthma: a pilot randomised controlled trial.
Summary
In this 7-month randomized controlled trial, children aged 1-6 years with asthma attacks triggered mostly by colds, will receive a high dose of vitamin D or a placebo every 3.5 months during their usual clinic visit. This study will test whether children receiving a high dose of vitamin D have less frequent and less severe asthma exacerbations compared with those receiving placebo.The study will also document the safety profile of this strategy.
Linked Publications (2)
-
Impact of two oral doses of 100,000 IU of vitamin D<sub>3</sub> in preschoolers with viral-induced asthma: a pilot randomised controlled trial.
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Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline in Serum 25OHD |
4.3; 9.6 | — |
| SECONDARY Number of Participants With Total 25OHD ≥75 Nmol/L |
9; 12; 8; 10 | — |
| SECONDARY Emergency Department Visit for an Asthma Flare-up |
1.00; 1.04 | — |
Eligibility Criteria
Inclusion Criteria
- age 1-5 years
- physician-diagnosed asthma as per the Global Initiative for Asthma (GINA) guidelines
- URTIs as the main asthma trigger (parental report)
- ≥4 URTIs in the past 12 months (parental report)
- ≥1 asthma exacerbation requiring rescue oral corticosteroids (OCS) in the past 6 months or ≥2 in the past 12 months
Exclusion Criteria
- intake or intention to use more than 400 IU/day of vitamin D supplement
- extreme prematurity ( 1000 IU/ day in last 3 months
- anticipated difficult follow-up (unable to attend clinic visits; plan to leave the province).
Data sourced from ClinicalTrials.gov (NCT02197702) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.