Phase 2
Completed N=5
Study 3: Minocycline Decreases Microglia Activation
Source: ClinicalTrials.gov NCT02213575 ↗Enrolled (actual)
5
Serious AEs
0.0%
Results posted
Jul 2025
Primary outcomePrimary: PET Changes in the Paraventricular Nucleus From Baseline to 26 Weeks. — 0.0350 Binding Potential (non-displaceable)
Summary
This study is a mechanistic study that will enroll 9 subjects who are participating in NCT02133872 (which is designed to evaluate minocycline to test the hypothesis that minocycline treatment would produce antihypertensive effects in drug-resistant neurogenic hypertensive individuals) to test whether the antihypertensive effect of minocycline is associated with a decrease in activated microglia in central nervous system autonomic regions as evidenced by changes in PET and MRI imaging.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY PET Changes in the Paraventricular Nucleus From Baseline to 26 Weeks. |
0.0350 | — |
Eligibility Criteria
Inclusion Criteria for Minocycline Subjects:
- Subjects participating in Study 1 will be eligible to participate.
- (For Study 3 Participants only) Willing to travel to Montreal, Canada for specialized imaging of the participant's brain using magnetic resonance imaging (MRI), positron emission tomography (PET) scanning, Autonomic Nervous System Testing and blood drawing- if participant qualifies
Exclusion Criteria for Minocycline Subjects:
-Female participants with positive pregnancy test.
Inclusion Criteria for Controls:
- No diagnosis of neurogenic (treatment-resistant) hypertension.
- Not treated with minocycline.
- Willing to travel to Montreal, Canada for brain imaging and testing.
- Able to provide informed consent.
Exclusion Criteria for Controls:
-Female participants with positive pregnancy test.
Data sourced from ClinicalTrials.gov (NCT02213575). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.