N/A
Completed N=90
Pilot Study on Pairing Sedation Strategies and Weaning
Source: ClinicalTrials.gov NCT02219659 ↗Enrolled (actual)
90
Serious AEs
2.3%
Results posted
May 2024
Primary outcomePrimary: Study Feasibility — 91; 97; 93 Percentage of study days
Summary
A three-arm, randomized, pilot study, to assess the feasibility for the analgesia-first sedation (AFS) study arm/intervention (Fentanyl push first). The study will assess additional outcomes for all three (3) validated strategies for sedation and pain management.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Study Feasibility |
91; 97; 93 | — |
| SECONDARY ICU Length of Stay |
7; 7; 8 | — |
Eligibility Criteria
Inclusion Criteria
- ≥ 18 years of age
- Mechanically ventilated with an expected duration of MV ≥ 48 hours
- ICU team has initiated continuous sedative and/or /analgesic infusions
Exclusion criteria
- Admission after resuscitation from cardiac arrest
- Admission with traumatic brain injury or another acute neurologic event (e,g. stroke, uncontrolled seizures).
- History of severe dementia
- Admission because of acute alcohol withdrawal or acute drug intoxication
- Administration of more than 24 hours of continuous sedation
- Allergy to fentanyl, midazolam, and/or propofol
- Lack of informed consent
Data sourced from ClinicalTrials.gov (NCT02219659). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.