N/A
Completed N=53
Electrical Stimulation in Patients With Prolonged Mechanical Ventilation
Source: ClinicalTrials.gov NCT02227810 ↗Enrolled (actual)
53
Serious AEs
—
Results posted
Mar 2017
Primary outcomePrimary: Level of Activity of Daily Life — 25.2; 32.0 units on a scale — p=0.652
Summary
Muscle atrophy and diaphragm dysfunction are common complication in patients with prolong mechanical ventilator (PMV) and is associated with increased rate of weaning failure and days of hospitalization. Electrical stimulation (ES) has been shown to be beneficial in patients with severe chronic heart failure and chronic obstructive pulmonary disease. The purpose of this study is to examine the effects of ES on skeletal muscle function, pulmonary mechanics and hospitalization outcomes in patients with PMV.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Level of Activity of Daily Life |
25.2; 32.0 | 0.652 |
| PRIMARY Muscle Strength |
1.7; 2.7 | 0.051 |
| PRIMARY Pulmonary Function |
164.7; 214.4 | 0.051 |
| SECONDARY Hospitalization Outcomes |
34.2; 32.3 | 0.792 |
Eligibility Criteria
Inclusion Criteria
- age>20 years old
- mechanical ventilation for more than 6 h/ day for more than 21 days -- medical stability (arterial blood gas value hydrogen power(pH): 7.35-7.45, atrial oxygen pressure(PaO2): 60 mmHg at 40% fraction of inspired oxygen inspired oxygen fraction (FiO2), absence of signs and symptoms of infection, and hemodynamic stability);
Exclusion Criteria
- signs of acute infection (BT>38.5℃，WBC>12000 or 35kg/m2
Data sourced from ClinicalTrials.gov (NCT02227810). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.