Phase 4
Completed N=515
PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement
Post-op Pain
Source: ClinicalTrials.gov NCT02244619 ↗
Enrolled (actual)
515
Serious AEs
0.0%
Results posted
Jul 2017
Primary outcomePrimary: Total Post-operative Use of Opioids — 21.7; 21.7 Morphine milligram equivalents (MME)
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The purpose of the study is to evaluate post-op pain requirements in patients undergoing hip or knee replacement surgery who perioperatively receive either Oral acetaminophen or IV acetaminophen
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Total Post-operative Use of Opioids |
21.7; 21.7 | — |
| SECONDARY Patient-rated Pain in the Post-operative Period |
3.6; 3.4 | — |
Eligibility Criteria
Inclusion Criteria
- 18 years of age and older
- Able to provide written consent
- Able to read and write in English
- Weighing over 50 kg
- Will undergo total hip or total knee joint replacement
Exclusion Criteria
- Non-verbal patients
- Unable to use numeric pain scale
- Allergic to the test article
- Documented hepatic impairment or failure
- Current illicit drug use
- Requires traumatic or emergent surgery
- Pregnant women
- Women who are breastfeeding
- Prisoners
- Cognitively impaired requiring Legally Authorized Representative (LAR) or Power of Attorney (POA)
- Unable to swallow oral capsules
Data sourced from ClinicalTrials.gov (NCT02244619). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.