N/A
N=21
Protein Quality on Appetite Control, Reward-driven Eating, & Subsequent Food Intake
Appetite and General Nutritional Disorders
Bottom Line
View on ClinicalTrials.gov: NCT02285907 ↗Enrolled (actual)
21
Serious AEs
0.0%
Results posted
Mar 2018
Primary outcome: Primary: Eating Initiation — 250; 270; 245; 250 minutes
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Macronutrient and Fiber Matched BEEF (Other); Macronutrient and Fiber Matched SOY (Other); Serving Size Matched BEEF (Other); Serving Size Matched SOY (Other)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Missouri-Columbia
- Primary completion
- Dec 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Eating Initiation |
250; 270; 245; 250 | — |
| PRIMARY Subsequent Food Intake |
240; 970; 920; 900 | — |
| PRIMARY Net Incremental Area Under the Curve (niAUC) of Perceived Hunger and Fullness |
45; -2840; -1360; 745; 2440; 3320 | — |
| PRIMARY Net Incremental Area Under the Curve (niAUC) of Plasma Total Glucagon-like Peptide (GLP-1) and Total Peptide YY (PYY) |
4100; 2790; 2120; 4870; 1590; 1330 | — |
| PRIMARY Food Cue-stimulate fMRI Brain Scans |
-22; 7; -30; -7 | — |
| SECONDARY Plasma Amino Acids |
0.24; -0.78; 4.01; 0.03; 0.64; 0.04 | — |
Summary
To determine whether the consumption of a beef-rich lunch improves appetite control, satiety, and energy intake regulation while reducing food reward and food cravings compared to the consumption of a soy-rich lunch when matched for macronutrients and fiber content or when match for serving size. The mechanisms of action surrounding the differential responses of beef versus soy proteins were also explored.
Eligibility Criteria
Inclusion Criteria
- Age range 18-30 y
- Normal to Overweight (BMI: 18-29.9 kg/m2)
- No metabolic, psychological, or neurological diseases/conditions
- Not currently/previously on a weight loss or other special diet (in the past 6 months)
- Not a vegetarian
- Right-handed (necessary for the fMRI analyses)
- Not pregnant
- Meets the MU-Brain Imaging Center Screening Criteria
- Have not given blood (for the American Red Cross in the past 6 months)
Exclusion Criteria
- Age >30 y and 29.9 kg/m2)
- Clinically diagnosed with diabetes (Type I or Type II), having an eating disorder, or having any other metabolic, psychological, or neurological diseases/conditions that would influence the study outcomes.
- Currently/previously on a weight loss or other special diet (in the past 6 months)
- Left-handed
- Claustrophobic (≥ 2 past bouts of claustrophobia when exposure to small spaces)
- Do not meet the fMRI criteria established by the MU-BIC (regarding metal implants, etc.)
- Pregnant
- Does not meeting the MU-Brain Imaging Center screening criteria
- Have given blood (for the American Red Cross) in the past 6 months or plan to give blood in the following 6 months
Data sourced from ClinicalTrials.gov (NCT02285907). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.