Phase 4
Completed N=87
Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study
Orthostatic; Hypotension, Neurogenic
Source: ClinicalTrials.gov NCT02308124 ↗
Enrolled (actual)
87
Serious AEs
0.0%
Results posted
Apr 2017
Primary outcomePrimary: Change in Orthostatic BP Drop — 11.1; 13.6; 8.9; 7.5 mmHg
◆ Published Evidence
Established
50citations · ~6 / year
Efficacy of single or combined midodrine and pyridostigmine in orthostatic hypotension.
Summary
Compare the effect of treatment of midodrine and pyridostigmine in neurogenic orthostatic hypotension and investigate the quality of life of treatment of neurogenic orthostatic hypotension.
Linked Publications
-
Efficacy of single or combined midodrine and pyridostigmine in orthostatic hypotension.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Orthostatic BP Drop |
11.1; 13.6; 8.9; 7.5; 11.1; 7.4 | — |
| SECONDARY Change of the Orthostatic Hypotension Associated Symptom Questionnaire (OH Questionnaire (OHQ)). |
-16.2; -17.2; -12.6 | — |
| SECONDARY Change of the Depression Score (Beck Depression Inventory-II ) |
-6.8; -7.8; -3.5 | — |
| SECONDARY Short-form 36 Version 2 |
5.6; 4.2; 2.7 | — |
| SECONDARY Changes in Health-related Quality of Life |
5.0; 6.7; 0.4 | — |
Eligibility Criteria
Inclusion Criteria
- age >=18 patients who complained of dizziness
- Orthostatic hypotension after 3-minute standing (systolic blood pressure drop >=20 or diastolic blood pressure drop >=10
Exclusion Criteria
- Drug-induced hypotension, if necessary, evaluate patient after discontinuing the causative drug for one month
- Heart failure or Chronic renal failure
- Patients who cannot or do not want to write questionaires.
- Poor drug compliance
Data sourced from ClinicalTrials.gov (NCT02308124) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.