N/A
N=90
Acquisition of Responses to a Methamphetamine-associated Cue in Healthy Humans
Substance Abuse
Bottom Line
View on ClinicalTrials.gov: NCT02323048 ↗Enrolled (actual)
90
Serious AEs
0.0%
Results posted
Jul 2018
Primary outcome: Primary: Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Subscales of the Drug Effects Questionnaire — 50.39; 45.25; 41.22; 48.55 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- methamphetamine (Drug); placebo (Drug)
- Age
- Adult · 21+ yrs
- Sex
- All
- Sponsor
- University of Chicago
- Primary completion
- Nov 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Subjective Effects as Assessed by Score on "Feel Drug", "Feel High", "Like Drug", and "Want More" Subscales of the Drug Effects Questionnaire |
50.39; 45.25; 41.22; 48.55; 42.22; 68.85 | — |
Summary
The aim of the study is to extend our investigations of drug-associated conditioning with healthy volunteers. The investigators have recently completed a pilot study demonstrating that subjects show an increase in self-reported preference for a visual stimulus paired with stimulant drug administration. Furthermore, our pilot data suggest that methamphetamine acts synergistically with rewards in the environment, such that this conditioning effect is facilitated by experiencing the drug in the presence of rewarding, or positive events, such as earning money. The investigators now aim to extend these findings by assessing not only self-reported preference, but also attentional and psychophysiological (electromyogram; EMG) responses to the drug-associated stimuli.
Eligibility Criteria
Inclusion Criteria
- BMI of 19-26kg/m, high school education,
- fluency in English,
- resting blood pressure less than140/90mmHg and consumption of less than 4 standard alcohol or caffeinated drinks per day.
Exclusion Criteria
- current substance abuse or lifetime substance dependence,
- regular medication,
- history of cardiovascular illness,
- current major Axis I DSM-IV disorder (APA, 2004),
- mood disorder or psychotic symptoms within the past year.
- Shift workers and pregnant or nursing mothers will also be excluded.
Data sourced from ClinicalTrials.gov (NCT02323048). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.