N/A
Completed N=42
The Effect of Different Volumes of Physical Exercise on the Immune System
Immune System Diseases · oxidative stress
Source: ClinicalTrials.gov NCT02331446 ↗
Enrolled (actual)
42
Serious AEs
0.0%
Results posted
Aug 2016
Primary outcomePrimary: Change in Interleukin-6 — 4.60; 4.58; 4.50; 5.27 pg/mL
Summary
The investigators will do an intervention on four groups of previously sedentary post-menopausal women which consists: group 1 - 30 minutes per day of physical protocol; group 2 - 50 minutes per day of physical protocol; group 3 - 70 minutes per day of physical protocol; group 4 - sedentary control women. The protocol consists of three sessions per week of concurrent training (half session with aerobic training and the other part with weight training). Inflammatory and oxidative parameters will be analyzed and the investigators hypothesized that 90 minutes per week of concurrent training (group 1) will reduce the inflammatory parameters and the oxidative stress, and this improvements will be greater so much as the longer the sessions (a dose-response effect). The physical activity practiced out of the intervention will be controlled by a questionnaire (the commuting and leisure sections of the International Physical Activity Questionnaire) and the food intake by a 24-hour food recall.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Interleukin-6 |
4.60; 4.58; 4.50; 5.27; 3.62; 4.14 | — |
| PRIMARY Change in Adenosine Deaminase Activity |
31.12; 29.94; 31.83; 25.91; 42.11; 42.54 | — |
| PRIMARY Change in Butyrylcholinesterase Activity |
9.35; 10.83; 7.44; 7.31; 10.07; 11.46 | — |
| PRIMARY Change in Thiobarbituric Acid Reactive Substances |
0.100; 0.144; 0.131; 0.137; 0.119; 0.159 | — |
| PRIMARY Change in Total Thiol Content |
9.00; 7.74; 7.73; 7.07; 12.26; 12.10 | — |
| PRIMARY Change in Glutathione Peroxidase Activity |
87.32; 63.69; 73.53; 65.31; 90.24; 91.26 | — |
| PRIMARY Change in Superoxide Dismutase Activity |
6.10; 5.31; 5.72; 4.67; 6.04; 5.04 | — |
| SECONDARY Change in Performance in the Six-minute Walk Test |
466.49; 515.78; 552.62; 539.77; 514.5; 581.02 | — |
| SECONDARY Change in Handgrip Strength |
23.61; 23.80; 25.03; 24.81; 22.98; 26.56 | — |
Eligibility Criteria
Inclusion Criteria
- Women have to be in the postmenopausal period, without physical disorders.
Exclusion Criteria
- Women who answer positively to, at least, one of the issues of the PAR-Q instrument;
- Women with diabetes and/or cancer history;
- Women who underwent oophorectomy.
Data sourced from ClinicalTrials.gov (NCT02331446). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.