N/A
Completed N=84
A Pilot Study to Assess the Amnesic Properties of Dexmedetomidine in Pediatric Patients
Memory · Dexmedetomidine
Source: ClinicalTrials.gov NCT02354378 ↗
Enrolled (actual)
84
Serious AEs
0.0%
Results posted
Feb 2019
Primary outcomePrimary: Sedation Threshold — 26.8; 38.9 Number of Memory Cards
Summary
The goal of this study is to determine the effects of dexmedetomidine on memory and recall of children who are receiving dexmedetomidine sedation administered for magnetic resonance imaging (MRI) studies. Dexmedetomidine is currently the standard drug for sedation for diagnostic (MRI, computerized tomography (CT) and Nuclear Medicine) radiological studies at Boston Children's Hospital (BCH). The effect of dexmedetomidine on memory and recall in children has not been studied.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Sedation Threshold |
26.8; 38.9 | — |
| SECONDARY Memory Threshold |
35.1; 50 | — |
Eligibility Criteria
Inclusion Criteria
- The patient must be between 4 and 14 yrs of age and be undergoing a therapeutic or diagnostic procedure with or without sedation
- The patient must be able to comprehend and perform the task (naming pictures)
- The patient must have a minimum weight of 8 kg
Exclusion Criteria
- Allergy to Dexmedetomidine (for those patients requiring sedation)
- Procedure of short duration (< 15 min)
- Pregnancy
- Recent use (within 5 half-lives) of centrally acting medications that could affect concentration (e.g. diphenhydramine)
Data sourced from ClinicalTrials.gov (NCT02354378). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.