Phase 4
N=70
The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis
Chronic Periodontitis
Bottom Line
View on ClinicalTrials.gov: NCT02355977 ↗Enrolled (actual)
70
Serious AEs
0.0%
Results posted
Dec 2015
Primary outcome: Primary: Pocket Depth — 4.34; 4.81; 4.5 mm
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- minocycline (Drug); surface and root planning (Procedure)
- Age
- Pediatric, Adult, Older Adult
- Sex
- All
- Sponsor
- Zhejiang University
- Primary completion
- Sep 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pocket Depth |
4.34; 4.81; 4.5 | — |
| SECONDARY Bleeding on Probing |
1.42; 1.23; 1.42 | — |
| SECONDARY Bacterial Load |
5.55; 4.32; 4.77; 6.77; 6.37; 6.72 | — |
Summary
To evaluate the respective or combinatory efficacy of locally delivered 2% Minocycline (MO) and surface and root planning (SRP) by assessing both clinical parameters and the loads of four main periodontal pathogens in treating chronic periodontitis.
Eligibility Criteria
Inclusion Criteria
- diagnosed with moderate or severe chronic periodontal disease, and exhibited bleeding on probing and attachment loss, with radiographic alveolar bone loss in four or more teeth
Exclusion Criteria
- pregnant, had used antibiotics within the last 3 months, had periodontal therapy in the past 6 months or had systemic diseases such as heart disease or hypertension
Data sourced from ClinicalTrials.gov (NCT02355977). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.