Phase 4 Completed N=70 Randomized Single-blind Treatment

The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis

Periodontitis

Source: ClinicalTrials.gov NCT02355977 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2015

Primary outcomePrimary: Pocket Depth — 4.34; 4.81; 4.5 mm

Summary

To evaluate the respective or combinatory efficacy of locally delivered 2% Minocycline (MO) and surface and root planning (SRP) by assessing both clinical parameters and the loads of four main periodontal pathogens in treating chronic periodontitis.

Outcome Measures

Outcome	Result	p-value
PRIMARY Pocket Depth	4.34; 4.81; 4.5	—
SECONDARY Bleeding on Probing	1.42; 1.23; 1.42	—
SECONDARY Bacterial Load	5.55; 4.32; 4.77; 6.77; 6.37; 6.72	—

Eligibility Criteria

Inclusion Criteria

diagnosed with moderate or severe chronic periodontal disease, and exhibited bleeding on probing and attachment loss, with radiographic alveolar bone loss in four or more teeth

Exclusion Criteria

pregnant, had used antibiotics within the last 3 months, had periodontal therapy in the past 6 months or had systemic diseases such as heart disease or hypertension

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02355977). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.