Phase 4
Completed N=68
Does the Addition of Epinephrine Prolong the Duration of Spinal Anesthesia for Repeat Cesarean Section?
Spinal Anesthesia · Cesarean section
Source: ClinicalTrials.gov NCT02369510 ↗
Enrolled (actual)
68
Serious AEs
0.0%
Results posted
Aug 2017
Primary outcomePrimary: Sensory Recovery — 135; 165; 120 minutes
◆ Published Evidence
Established
26citations · ~3 / year
The Effect of Adding Subarachnoid Epinephrine to Hyperbaric Bupivacaine and Morphine for Repeat Cesarean Delivery: A Double-Blind Prospective Randomized Control Trial.
Summary
The purpose of this study is to investigate whether the addition of a medication called epinephrine to spinal medications prolongs the duration of the anesthesia. The medication standardly used in spinal anesthesia is a local anesthetic (bupivacaine) and an opiate pain medication (morphine). These medications typically last about 2 hours. The investigators want to determine if adding epinephrine to the spinal medications prolongs the anesthetic without side effects. A longer duration of anesthesia may be useful in prolonged repeat cesarean section. Epinephrine is known to prolong the action of some local anesthetics, but the investigators want to specifically study combining it with the medications the investigators use regularly for cesarean section.
You may qualify to take part in this research study because you are having a repeat cesarean section. Repeat cesarean sections sometimes last longer than 2 hours. The investigators want to determine if epinephrine will prolong the anesthetic.
Linked Publications
-
The Effect of Adding Subarachnoid Epinephrine to Hyperbaric Bupivacaine and Morphine for Repeat Cesarean Delivery: A Double-Blind Prospective Randomized Control Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Sensory Recovery |
135; 165; 120 | — |
| SECONDARY Motor Recovery |
150; 172; 120 | — |
| SECONDARY Block Onset |
6; 8; 8 | — |
| SECONDARY Number of Participants With Hypotension |
5; 2; 8; 3; 9; 3 | — |
| SECONDARY Adequacy of Anesthesia |
0; 0; 0 | — |
| SECONDARY Patient Satisfaction |
90; 85; 87 | — |
| SECONDARY Incidence of Nausea and Vomiting |
2; 0; 4; 3; 6; 1 | — |
| SECONDARY Incidence of Pruritus |
— | — |
Eligibility Criteria
Inclusion Criteria
- Non-emergent repeat cesarean section
- Neuraxial anesthesia as the planned primary anesthetic
- Informed consent obtained
- Females age 18-50
Exclusion Criteria
- Emergency cesarean section
- Anesthetic other than neuraxial
- Allergy to local anesthetics, morphine, or epinephrine
- Pre-existing sensory/motor deficit
Data sourced from ClinicalTrials.gov (NCT02369510) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.