N/A
N=31
A Biomechanical Exercise Program for Knee OA
Osteoarthritis, Knee
Bottom Line
View on ClinicalTrials.gov: NCT02370667 ↗Enrolled (actual)
31
Serious AEs
0.0%
Results posted
Mar 2017
Primary outcome: Primary: Change in Lower Extremity Function — 10.6; 7.6; -6.4 Change in scores on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Biomechanical Exercise (BE) (Other); Traditional Exercise (TE) (Other); Meditation Control (M) (Other)
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- Female
- Sponsor
- McMaster University
- Primary completion
- Jul 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Lower Extremity Function |
10.6; 7.6; -6.4 | — |
| SECONDARY Change in Self-reported Knee Pain |
21.5; 8.3; -2.1; -23.7; -14.3; -4.2 | — |
| SECONDARY Change in Arthritis-related Self-efficacy |
0.2; 2.6; 0.7 | — |
| SECONDARY Change in Depression Status |
1.0; 1.0; -3.6 | — |
| SECONDARY Change in Frailty Status |
0.3; -0.2; -1.1 | — |
| SECONDARY Change in Mobility Performance (Six-Minute Walk Test) |
59.3; 54.0; 19.1 | — |
| SECONDARY Change in Mobility Performance (40m Walk Test) |
-3.9; -2.9; 4.0 | — |
| SECONDARY Change in Mobility Performance (30-second Chair Stand Test) |
3.4; 2.5; 1.8 | — |
| SECONDARY Change in Mobility Performance (Timed Up and Go Test) |
-1.3; -0.3; 0.2 | — |
| SECONDARY Change in Mobility Performance (Stair Ascent) |
-1.7; -0.7; 1.9 | — |
| SECONDARY Change in Isometric Knee Extensor and Flexor Strength |
0.1; 0.0; 0.0; 0.0; 0.1; 0.0 | — |
| SECONDARY Change in Isokinetic Knee Extensor and Flexor Power |
0.3; 0.8; -0.1 | — |
| SECONDARY Change in Grip Strength (Absolute) |
0.4; -0.1; 1.2; 1.0; -1.5; 0.1 | — |
| SECONDARY Change in Grip Strength (Relative) |
0.0; 0.0; 0.0; 0.0; 0.0; 0.0 | — |
| SECONDARY Change in Cardiovascular Fitness |
— | — |
| SECONDARY Change in Muscle and Fat Volume |
— | — |
| SECONDARY Change in Cartilage Morphology |
-3.7; -1.0; -1.3; 3.2; -2.2; -1.2 | — |
| SECONDARY Change in Inflammatory Markers (IL6, TNF, IL10) |
-0.6; 0.0; 0.1; -3.4; 0.3; 0.3 | — |
| SECONDARY Change in Inflammatory Markers (CRP) |
16.3; -12.3; -12.0 | — |
Summary
Prescribing exercise for people with painful knee osteoarthritis (OA) is essential for pain management, improved function, and chronic disease prevention. Exercise that decreases joint exposure to damaging loading while eliciting adequate muscular activation for strength improvements is ideal. The purpose of this 3-arm RCT is to compare mobility, strength, pain, and MRI outcomes between the low-loading biomechanical exercise program (BE), a traditional exercise program for knee OA (TE), and a control group completing meditation classes (M).
Eligibility Criteria
Inclusion Criteria
- 50 years of age or older
- Knee pain on most days of the week
- Less than 30 minutes of morning stiffness
- Bony enlargement
- Bony tenderness to palpation
- Signs of inflammation
- Able to safely climb 2 flights of stairs without aid
Exclusion Criteria
- Any other forms of arthritis
- Osteoporosis
- History of patellofemoral symptoms
- Active non-arthritic knee disease
- Knee surgery
- Use of cane or walking aid
- Unstable heart condition
- Neurological conditions
- Skin allergy to medical tape
- Hip or ankle injuries in past 3 months
- Any injuries that would prohibit participation in yoga
- Ipsilateral hip or ankle conditions
- Currently receiving cancer treatment
- Currently pregnant
Data sourced from ClinicalTrials.gov (NCT02370667). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.