N/A N=40 Randomized Single-blind Treatment

Platelet-rich Fibrin and Connective Tissue Graft in Recession Treatment

Gingival Recession

Bottom Line

View on ClinicalTrials.gov: NCT02397122 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2018

Primary outcome: Primary: Vertical Recession — 3.35; 3.20; 0.38; 0.65 mm — p=0.259

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: platelet-rich fibrin (Biological); connective tissue graft (Procedure); coronally advanced flap (Procedure)
Age: Pediatric, Adult, Older Adult
Sex: All
Sponsor: Kırıkkale University
Primary completion: Dec 2013

Outcome Measures

Outcome	Result	p-value
PRIMARY Vertical Recession	3.35; 3.20; 0.38; 0.65; 0.35; 0.65	0.259
SECONDARY Horizontal Recession	3.8; 3; 0; 1; 0; 1	0.067
SECONDARY Probing Depth	1; 1; 1; 1; 1; 1	0.298
SECONDARY Attachment Level	4.5; 4; 1; 2; 1; 1.8	0.136
SECONDARY Keratinized Tissue Width	3; 2.8; 4; 3.5; 4; 3.8	0.245
SECONDARY Tissue Thickness	0.9; 0.9; 1.9; 1.6; 1.9; 1.5	0.946

Summary

The aim of the trial is to evaluate the effectiveness of coronally advanced flap (CAF)+connective tissue graft(CTG)+platelet-rich fibrin(PRF) combination in Miller I and II recession treatment by comparing with CAF+CTG. 40 patients were surgically treated either with CAF+CTG+PRF (test group) or CAF+CTG (control group). Clinical parameters of plaque index (PI), gingival index (GI), vertical recession (VR), probing depth (PD), attachment level (AL), keratinized tissue width (KTW), horizontal recession (HR), MGJ localization (L-MGJ), tissue thickness (TT) were recorded at baseline, 3 months (PS1) and 6 months (PS2) post-surgery. Root coverage (RC), complete RC (CRC), attachment gain (AG), and keratinized tissue change (KTC) were also calculated.

Eligibility Criteria

Inclusion Criteria

Systemically healthy
Single Miller type I or II recession defect ≥ 3 mm localized to anterior/premolar area
No alveolar bone loss
Identifiable cemento-enamel junction
Probing depth ≤3mm

Exclusion Criteria

Smoking
Pregnancy
History of periodontal surgery in last two years
Mobility
Excessive occlusal contacts
Caries
Loss of vitality

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Data sourced from ClinicalTrials.gov (NCT02397122). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.