N/A
N=39
Early-onset Obesity and Cognitive Impairment in Children With Pseudohypoparathyroidism
Pseudohypoparathyroidism · Albright Hereditary Osteodystrophy
Bottom Line
View on ClinicalTrials.gov: NCT02411461 ↗Enrolled (actual)
39
Serious AEs
0.0%
Results posted
Jun 2018
Primary outcome: Primary: Intelligence Quotient — 85.9; 104.3; 103.2 units on a scale
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Pediatric, Adult · 6+ yrs
- Sex
- All
- Sponsor
- Vanderbilt University Medical Center
- Primary completion
- Jan 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Intelligence Quotient |
85.9; 104.3; 103.2 | — |
Summary
Pseudohypoparathyroidism type 1a (PHP1a) is a rare disease that causes childhood obesity and learning difficulties. This study will investigate eating behaviors and perform cognitive testing on children with PHP1a. The investigators will compare their results to those of healthy siblings and other obese children.
Eligibility Criteria
Inclusion Criteria
- Clinical diagnosis of PHP1a, sibling of a patient with PHP1a or matched obese control
Exclusion Criteria (PHP1a):
- Treatment with appetite-altering drug or initiation of a new weight loss program in the past 3 months
- Type 2 diabetes
Exclusion Criteria (Controls):
- Obesity due to a genetic syndrome, growth hormone deficiency, untreated hypothyroidism, Cushing syndrome or exogenous glucocorticoid administration
- Weight loss greater than 10% over the previous 6 months
- Autism or other significant learning disorder
- Type 2 diabetes
- Other significant medical condition
Data sourced from ClinicalTrials.gov (NCT02411461). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.