N/A N=28 Randomized Triple-blind Basic Science

Individual Differences in the Response to Drugs

Healthy

Bottom Line

View on ClinicalTrials.gov: NCT02485158 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Nov 2016

Primary outcome: Primary: Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration — 4.79; 12.83; 11.08; 12.17 units on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: THC (Drug); AMP (Drug); ALC (Drug); Placebo capsules (Drug); Placebo beverage (Drug)
Age: Adult · 21+ yrs
Sex: All
Sponsor: University of Chicago
Primary completion: Dec 2013

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration	4.79; 12.83; 11.08; 12.17; 9.38; 4.5	—
PRIMARY Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration	43.42; 76.83; 38.25; 21.58; 17.83; 18.63	—
PRIMARY Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration	34.92; 61.21; 31.54; 16.46; 12.75; 13.17	—
PRIMARY Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion	27.08; 43.92; 24.08; 11.92; 7.96; 7.88	—
PRIMARY Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration	19.79; 30.83; 18.63; 5.83; 4.63; 4.63	—
PRIMARY Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration	16.13; 22.21; 15.67; 3.5; 2.08; 2.54	—
PRIMARY Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration	11.08; 12.88; 5.79; 2.17; 0.96; 1.08	—
PRIMARY Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration	-0.17; 0.25; -0.04; -0.25; -0.17; 0.54	—
PRIMARY Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration	2.88; 1.92; 0.17; 0; -0.33; 0.71	—
PRIMARY Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration	2.96; 0.29; 0; -0.33; -0.58; -0.08	—
PRIMARY Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration	2.17; -0.33; -0.08; -0.17; -0.71; -0.04	—
PRIMARY Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration	2.29; -0.54; -0.17; -0.13; -0.54; -0.08	—
PRIMARY Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration	1.58; -0.75; -0.21; -0.04; -0.33; -0.17	—
PRIMARY Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration	1.0; -0.71; -0.46; -0.17; -0.54; 0.08	—

Summary

The purpose of this study is to examine whether individual differences in acute responses to drugs co-vary across three drugs from different drug classes: alcohol, amphetamine and delta-9-tetrahydrocannabinol (THC). The investigators hypothesize that individuals who experience greater rewarding effects from one drug will also experience more rewarding effects from the other drugs.

Eligibility Criteria

Inclusion Criteria

English fluency
High school education
BMI between 19 and 26
Individuals who report drinking at least 4 alcoholic drinks on one occasion in the past month

Exclusion Criteria

individuals with a medical condition contraindicating study participation, as determined by our physician
individuals regularly using any contraindicated medications
individuals with current dependence on any drug or past dependence on alcohol, marijuana or stimulants
individuals with a past year DSM-IV Axis I mood, anxiety, eating, or psychotic disorder
women who are pregnant, nursing, or planning to become pregnant in the next 3 months
individuals who drink more than 10 alcoholic drinks per week
individuals who currently use i) any illicit drug weekly or more frequently, ii) stimulant prescription drugs, iii) more than 10 cigarettes per week, and iv) more than 3 cups of coffee per day

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02485158). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.