Phase 2
N=46
Ombitasvir/ABT-450/Ritonavir and Dasabuvir Therapy With Low Dose Ribavirin (RBV), Full Dose RBV or RBV Add-On in Treatment Naive Genotype 1a Hepatitis C Virus Infected Adults
Chronic Hepatitis C · Hepatitis C (HCV) · Hepatitis C Genotype 1a
Bottom Line
View on ClinicalTrials.gov: NCT02493855 ↗Enrolled (actual)
46
Serious AEs
2.2%
Results posted
May 2017
Primary outcome: Primary: Slope of the Second Phase Decline in Plasma HCV Ribonucleic Acid (RNA) Levels During Treatment — 0.0036; 0.0046; 0.0051 1/day — p=0.311
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Ombitasvir/ABT-450/Ritonavir (Drug); Dasabuvir (Drug); Ribavirin (RBV) (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- AbbVie
- Primary completion
- Apr 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Slope of the Second Phase Decline in Plasma HCV Ribonucleic Acid (RNA) Levels During Treatment |
0.0036; 0.0046; 0.0051 | 0.311 |
Summary
To evaluate the effect of ribavirin on second phase plasma hepatitis C virus (HCV) ribonucleic acid (RNA) decline in participants who receive ombitasvir/ABT-450/ritonavir and dasabuvir with full dose ribavirin, low dose ribavirin or without ribavirin for 2 weeks in treatment-naive HCV genotype (GT) 1a-infected adults.
Eligibility Criteria
Inclusion Criteria
- Screening laboratory result indicating HCV genotype 1 (GT1) a infection.
- Chronic HCV infection.
- Subjects must be non-cirrhotic.
- Subjects must be able to understand and adhere to the study visit schedule and all protocol requirements as well as voluntarily sign and date an institutional review board (IRB) approved informed consent.
Exclusion Criteria
- Women who are pregnant or breastfeeding.
- Positive test result for hepatitis B surface antigen (HBsAg) or anti-human immunodeficiency virus antibody (HIV Ab) positive immunoassay.
- Clinically significant abnormalities or co-morbidities, other than HCV infection, that make the subject unsuitable for this study or treatment.
- Current enrollment in another interventional clinical study. Previous use of any HCV treatments including pegylated interferon (pegIFN), ribavirin, or any direct acting antiviral agent, either investigational or approved, for HCV including protease inhibitors, nucleoside or non-nucleoside polymerase inhibitors, or nonstructural viral protein 5A (NS5A) inhibitors.
- History or solid organ transplant.
- Screening laboratory analysis that shows abnormal results.
Data sourced from ClinicalTrials.gov (NCT02493855). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.