Safety and Efficacy of PD0332991 (Palbociclib), a Cyclin-dependent Kinase 4 and 6 Inhibitor, in Patients With Oligodendroglioma or Recurrent Oligoastrocytoma Anaplastic With the Activity of the Protein RB Preserved

Inclusion Criteria

• Ability to understand and sign the informed consent approved by the Ethic Committee.
• Men or women aged greater than or equal to 18.
• Patients with oligodendroglioma anaplastic or oligoastrocytoma anaplastic according to WHO classification and histologically confirmed. Note: It can be included patients with oligoastrocytoma or oligodendroglioma G2 only if they have suffered a recurrence in which the diagnosis of the resection were G3.
• Patients in relapse after radiotherapy and one or two lines of chemotherapy. Note: Both previous radiotherapy and chemotherapy could be received in adjuvant therapy or previous recurrences. It is also accepted to be received concurrent chemoradiotherapy. In the secondary oligodendrogliomas or oligoastrocytomas anaplastic, the patients could have received chemotherapy and radiotherapy when the tumor was G2.
• All patients have to present positivity in immunohistochemical study for the RB protein in the tumor samples sent to the central lab.
• The cases must have 10 slides or a tumor block available from a biopsy or surgery.
• All patients have to show disease progression in a cerebral nuclear magnetic resonance.
• Interval of at least one week between the previous intracranial biopsy and the inclusion.
• Interval of at least 12 weeks between radiotherapy and the inclusion, unless: a) Recurrent tumor confirmed histologically b) recurrency showed in the NMR out of radiotherapy.
• Patients should have been recovered from previous therapies: 28 days since the end of any investigational product and since the end of any cytotoxic treatment.
• ECOG≤2
• Stable or decreasing dose of corticoids during the five days prior to the inclusion
• patients who have been suffered from a tumor resection in the last recurrence are eligible if:
• A good surgery recover
• there is a measurable or evaluable disease after surgery
• Good bone marrow function:
• Neutrophils ≥ 1500/mm3 (1.5x10e9/L)
• Platelet ≥ 100.000/mm3 (100 x 10e9)
• Hemoglobin ≥ 9 g/dL
• Seric creatinine ≤ 1.5 x LSN of the site or estimated clearance ≥ 60 ml/min calculated.
• Bilirubin ≤ 1.5 x LSN (if Gilbert's syndrome ≤ 3 xLSN) AST (SGOT) and/or ALT ≤ 3 x LSN; alkaline phosphatase ≤ 2.5 x LSN.
• Nor pregnant women nor breast-feeding women. Women with heterosexual activity should have a negative pregnant test before the inclusion in the study. Both women and men should use an accepted contraceptive method during the study treatment and 1 month after treatment completed.

Exclusion Criteria

• Presence of meningeal carcinomatosis disseminated.
• Concomitant treatment with other investigational products
• Previous treatment wih an investigational product that could be active for CDK4/6
• Any kind of surgery in the previous 2 weeks
• Presence of any clinically significant gastrointestinal abnormality that can affect oral administration, transit or absorption of study drug, such as the inability to take medication by mouth as tablets.
• Presence of any psychiatric or cognitive disorder that limits the understanding or the signature of informed consent and / or jeopardize the fulfillment of the requirements of this protocol.
• In the 7 days prior to the beginning of the treatment, to have received a treatment with: - Drugs inhibitor of the CYP3A4 - Drugs inductors of the CYP3A4 - Drugs that extends the QT interval
• QTc interval >480 msec, familiar history or personal of QT large Syndrome, QT short Syndrome, Brugada syndrome, QTc extension or Torsade de Pointes history
• Electrolyte disorder that may affect the QTc interval
• Significant or uncontrolled cardiovascular disease, including:
• Myocardial infarction within the previous 12 months
• Uncontrolled angina within the previous 6 months
• Congestive heart failure in the previous 6 months
• History of clinically significant ventricular arrhythmias of any type (as ventricular tachycardia, ventricular fibrillation or torsades de pointes)
• Hist