N/A
Completed N=20
Neuropsychological Rehabilitation of Spontaneous Confabulation
Memory Disorders
Source: ClinicalTrials.gov NCT02540772 ↗
Enrolled (actual)
20
Serious AEs
35.0%
Results posted
Mar 2016
Primary outcomePrimary: Number of Confabulations — 30.0; 29.9; 8.1; 35.5 Confabulations
Summary
Confabulators consistently generate false memories without intention to deceive and with great feeling of rightness. However, there is currently no known effective treatment for them. In order to fill this gap, the aim of this trial was to design a neuropsychological treatment based on the current theoretical models and test it experimentally in two groups of confabulators: experimental vs. control. The treatment consisted of some brief material that patients had to learn and recall at both immediate and delayed moments. After both recollections, patients were given feedback about their performance (errors and correct responses). Pre-treatment and post-treatment baselines were administered. Confabulators in the control group performed the baselines without treatment, and were then offered the treatment after the second baseline.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Confabulations |
30.0; 29.9; 8.1; 35.5 | — |
| PRIMARY Number of Correct Responses |
22.0; 20.9; 42.6; 22.0 | — |
| PRIMARY Number of Non-responses |
26.3; 29.5; 22.3; 19.2 | — |
| SECONDARY Number of Errors in Source Attribution |
25.1; 25.7; 12.2; 30.2 | — |
Eligibility Criteria
Inclusion Criteria
- The presence of spontaneous confabulations after acute brain injury, for at least three months and without clinical improvement (interfering with the patient's daily life with frequent arguments and exhaustive supervision).
- The presence of momentary confabulations in the Spanish adaptation of Dalla Barba provoked confabulation interview.
- Prior to injury, all patients should be completely independent for daily living.
Exclusion Criteria
- The presence of impairment in alertness.
- Dementia.
- Acute confusional state.
- A history of alcohol or drug abuse.
- Psychiatric antecedents.
Data sourced from ClinicalTrials.gov (NCT02540772). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.