N/A N=330 Randomized Treatment

Comparison of Hybrid and Bismuth Quadruple Therapies for Helicobacter Pylori Eradication

Helicobacter Pylori Infection

Bottom Line

View on ClinicalTrials.gov: NCT02541864 ↗

Enrolled (actual)

330

Serious AEs

0.0%

Results posted

Aug 2017

Primary outcome: Primary: Number of Participants in Which H. Pylori Was Eradicated — 154; 154 participants

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Bismuth quadruple therapy (Drug); Hybrid therapy (Drug)
Age: Adult, Older Adult · 20+ yrs
Sex: All
Sponsor: Kaohsiung Veterans General Hospital.
Primary completion: Aug 2015

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants in Which H. Pylori Was Eradicated	154; 154	—

Summary

According the Maastricht IV consensus report publish in the Gut 2012, bismuth containing quadruple therapy was suggested to be the first choice for eradication therapy of Helicobacter pylori in the area with high clarithromycin resistance. Whether hybrid therapy or 14-day bismuth containing quadruple therapy can replace standard triple therapy as the recommended first-line treatment is unknown. The investigators compared the efficacy of 14-day hybrid therapy and 14-day bismuth containing quadruple therapy in first-line treatment.

Eligibility Criteria

Inclusion Criteria

Consecutive H pylori-infected outpatients, at least 20 years of age, with endoscopically proven peptic ulcer diseases or gastritis

Exclusion Criteria

previous H pylori-eradication therapy
ingestion of antibiotics or bismuth within the prior 4 weeks
patients with allergic history to the medications used
patients with previous gastric surgery
the coexistence of serious concomitant illness (for example, decompensated liver cirrhosis, uremia)
pregnant women

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Data sourced from ClinicalTrials.gov (NCT02541864). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.