Phase 4
Completed N=20
The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold
Healthy
Source: ClinicalTrials.gov NCT02550093 ↗
Enrolled (actual)
20
Serious AEs
0.0%
Results posted
May 2022
Primary outcomePrimary: Hot and Cold Thermal Sensory Threshold for Pain at Baseline in Degrees Celsius. — 43.93; 43.0; 14.81; 13.33 degrees Celsius — p=.47
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
Oxytocin is neurohypophysial peptide that acts mainly as a neuromodulator in the brain.The vast majority of basic science studies suggested a large effect of oxytocin in minimizing acute pain.Few studies have demonstrated an association between plasma levels of oxytocin and pain in humans. Since addictive properties of oxytocin have not been described, the drug may have important application in the management of acute and chronic pain. No studies have examined the effect of intranasal oxytocin on pain sensitivity and threshold.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Hot and Cold Thermal Sensory Threshold for Pain at Baseline in Degrees Celsius. |
43.93; 43.0; 14.81; 13.33 | .47 |
| PRIMARY Hot and Cold Thermal Sensory Threshold for Pain at 45 Minutes in Degrees Celsius. |
43.60; 43.42; 15.68; 15.17 | 0.84 |
| PRIMARY Hot and Cold Thermal Sensory Threshold for Pain at 90 Minutes in Degrees Celsius. |
43.94; 43.95; 15.41; 12.96 | 0.92 |
| PRIMARY Mechanical Pain Threshold for Pain at Baseline in Grams. |
194.90; 223.31 | 0.60 |
| PRIMARY Mechanical Pain Threshold for Pain at 45 Minutes in Grams. |
195.07; 197.49 | 0.68 |
| PRIMARY Mechanical Pain Threshold for Pain at 90 Minutes in Grams. |
198.76; 208.77 | 0.62 |
| PRIMARY Suprathreshold Magnitude for Pain at Baseline Measured in Visual Analog Pain Scores. |
2.90; 3.02 | 0.97 |
| PRIMARY Suprathreshold Magnitude for Pain at 45 Minutes Measured in Visual Analog Pain Scores. |
2.58; 2.67 | 0.97 |
| PRIMARY Suprathreshold Magnitude for Pain at 90 Minutes Measured in Visual Analog Pain Scores. |
2.53; 2.29 | 0.61 |
| PRIMARY Thermal Wind-up Pain Assessment at Baseline |
3.59; 3.15 | 0.71 |
| PRIMARY Thermal Wind-up Pain at 45 Minutes |
2.99; 2.85 | 0.74 |
| PRIMARY Thermal Wind-up Pain at 90 Minutes |
2.82; 2.63 | 0.75 |
Eligibility Criteria
Inclusion Criteria
- Healthy males and females volunteers, English speaking
Exclusion Criteria
- Pregnancy, lactation, allergy to preservatives, mental disease, any chronic pain and any current use of analgesics, anxiety or depression.
Data sourced from ClinicalTrials.gov (NCT02550093). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.