N/A
Completed N=150
Dexmedetomidine or Dexmedetomidine Combined With Dexamethasone on Postoperative Nausea and Vomiting in Breast Cancer
Source: ClinicalTrials.gov NCT02550795 ↗Enrolled (actual)
150
Serious AEs
0.0%
Results posted
Aug 2020
Primary outcomePrimary: Postoperative Nausea (Numeric Rating Scale for Nausea) — 0; 0; 0 scores on a scale
Summary
Previous reports demonstrated that dexmedetomidine could reduce the incidence of postoperative nausea and vomiting (PONV). Dexamethason also had been commonly used for ajuvant drugs for preventing and reducing PONV. So investigator want to study about the effect of dexmedetomidine only or combined with dexamethasone for preventing PONV.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Postoperative Nausea (Numeric Rating Scale for Nausea) |
0; 0; 0 | — |
| SECONDARY Postoperative Vomiting (Number of Participants With Vomiting) |
4; 0; 0; 15; 6; 1 | — |
| SECONDARY Rhodes Index Score |
5; 0; 0; 3.5; 0; 0 | — |
Eligibility Criteria
Inclusion Criteria
- ASA Physical status I or II female scheduled for breast conserving surgery of modified radical mastectomy.
Exclusion Criteria
- uncontrolled cardiovascular disease
- history of chronic pain
- smoker
- previous history of steroid administraion
- neoajuvant chemotherapy
Data sourced from ClinicalTrials.gov (NCT02550795). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.