N/A
N=27,034
Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis
Postoperative Nausea and Vomiting
Bottom Line
View on ClinicalTrials.gov: NCT02625181 ↗Enrolled (actual)
27,034
Serious AEs
0.3%
Results posted
Mar 2019
Primary outcome: Primary: Adherence to PONV Guidelines — 666; 5260; 5863 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Automated recommendation at the start of the case (Procedure); Automated notification at the start of surgery (Procedure); Preoperative recommendations: by email (Procedure); Automated notification at the end of surgery (Procedure); Anesthesia Information Management System (AIMS) (Device); Perioperative Data Warehouse (PDW) (Device); General anesthesia (Procedure); Elective surgery (Procedure); Propofol (Drug); Sevoflurane (Drug); Isoflurane (Drug); Desflurane (Drug); Scopolamine (Drug); Droperidol (Drug); Haloperidol (Drug); Dexamethasone (Drug); Promethazine (Drug); Meclizine (Drug); Aprepitant (Drug); Metoclopramide (Drug); Fentanyl (Drug); Sufentanil (Drug); Alfentanil (Drug); Remifentanil (Drug); Morphine (Drug); Meperidine (Drug); Hydromorphone (Drug); Methadone (Drug); Oxycodone (Drug); Oxymorphone (Drug); Hydrocodone (Drug); Ketamine (Drug); Ondansetron (Drug); Granisetron (Drug); Dolasetron mesylate (Drug); Palonosetron (Drug); Tropisetron (Drug); Ramosetron (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Vanderbilt University
- Primary completion
- Nov 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Adherence to PONV Guidelines |
666; 5260; 5863 | — |
| SECONDARY PONV Incidence: Number of Participants With Postoperative Nausea and Vomiting |
139; 1323; 1343 | — |
| SECONDARY The Number of Prophylactic Interventions for PONV |
2.196; 2.176; 2.129 | — |
| SECONDARY Time to Discharge From the Postanesthesia Care Unit (PACU) |
266; 264; 266 | — |
Summary
The purpose of this study is to determine how automated recommendations are best presented to optimize the adherence to guidelines on prophylaxis for nausea and vomiting after surgery.
Eligibility Criteria
Inclusion Criteria
- All adult patients (18 years and older) that are scheduled for an elective surgical procedure under general anesthesia
Exclusion Criteria
- Patients undergoing emergency surgery or organ transplantation
- Patients that are transferred directly to the Intensive Care Unit after the end of the procedure
- Patients that die intraoperatively
- Procedures that only require a sedative level of anesthesia
Data sourced from ClinicalTrials.gov (NCT02625181). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.