Phase 4 Completed N=89 Randomized Double-blind Treatment

the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block

Opioid Use, Unspecified

Source: ClinicalTrials.gov NCT02653144 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jul 2020

Primary outcomePrimary: Opioid Requirements (Morphine Equivalents) — 15; 15; 22.5 morphine milligram equivalent

◆ Published Evidence

No publication linked

No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.

Summary

The purpose of the study is to determine if perineural dexmedetomidine can provide increased prolongation of analgesia when compared to perineural dexamethasone in patients receiving regional block for shoulder surgery. If so, dexmedetomidine may serve as a superior adjunct to peripheral nerve blocks in a rapidly evolving, ambulatory-centered surgical setting.

Outcome Measures

Outcome	Result	p-value
PRIMARY Opioid Requirements (Morphine Equivalents)	52.5; 30; 40	—
SECONDARY Opioid Requirements (Morphine Equivalents)	52.5; 30; 40	—
SECONDARY Time to Discharge From PACU to First Opioid Consumption	1280; 1130; 900	—
SECONDARY Return of Motor and Sensory Function	1280; 1130; 900	—

Eligibility Criteria

Inclusion Criteria

ASA 1 and 2
18-60 years old
Patients scheduled for ambulatory arthroscopic or open surgery

Exclusion Criteria

ASA 3 and 4
Pre-existing pain disorder
Regular consumption of chronic pain medication
Anatomical abnormalities of upper extremity
Known allergy or hypersensitivity to Ropivacaine or other amide local anesthetics
Known allergy to dexmedetomidine
Coagulopathy
Uncontrolled Diabetes

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02653144). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.