N/A N=7 Prevention

Effect of Nasal Continuous Positive Airway Pressure on The Pharyngeal Swallow in Neonates

Deglutition Disorders · Respiratory Distress Syndrome In Premature Infants · Respiratory Aspiration · Newborn, Premature

Bottom Line

View on ClinicalTrials.gov: NCT02661256 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jul 2019

Primary outcome: Primary: Pharyngeal Phase Dysphagia — 7; 7 Participants

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: NCPAP (Device); Varibar® Thin Liquid Barium Sulfate for Suspension (Dietary_supplement)
Age: Pediatric · 0+ yrs
Sex: All
Sponsor: NYU Langone Health
Primary completion: Aug 2015

Outcome Measures

Outcome	Result	p-value
PRIMARY Pharyngeal Phase Dysphagia	7; 7	—
SECONDARY Tracheal Aspiration	33.5; 14.6	—
SECONDARY Percentage of Laryngeal Length	43.7; 25.3	—
SECONDARY Silent Aspiration	7; 7	—
SECONDARY Nasopharyngeal Reflux	42.8; 44.2	—
SECONDARY Pharyngeal Residue	1; 3; 4; 4; 2; 0	—

Summary

Oral feeding of neonates while on nasal continuous positive airway pressure (NCPAP) is a common practice in many neonatal intensive care units (NICU) all over the country. However the safety of such practice has never been established. The Investigators hypothesize that mechanoreceptors, which should perceive sensory input from the liquid bolus, may be altered by the reception of pressurized airflow provided by the NCPAP, hence increase risk of aspiration. In this study, changes in the pharyngeal phase of swallowing were identified using video fluoroscopic swallow studies (VFSS) for infants while on NCPAP as compared to off NCPAP.

Eligibility Criteria

Inclusion Criteria

Infants in neonatal ICU requiring NCPAP and tolerating at least 50% of their total required intake by mouth from a bottle, as determined by their medical team.

Exclusion Criteria

Infants with other comorbidity such as upper airway anomalies, brain injury neuromuscular disease, life threatening congenital disease. Any symptomatic intercurrent acute disease e.g. infectious disease

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02661256). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.