N/A
N=34
Computed Tomography Arteriograms (CTA) Volume Dose Reduction Study
Aortic Aneurysm · Contrast Induced Nephropathy · Aortic and Arterial Anomalies
Bottom Line
View on ClinicalTrials.gov: NCT02669784 ↗Enrolled (actual)
34
Serious AEs
0.0%
Results posted
Jun 2019
Primary outcome: Primary: Ascending Sinotubular Junction Measurement — 246.4; 287.5 Hounsfield units
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Low Dose Contrast (Omnipaque) 40mL (Drug); Low Dose Contrast (Omnipaque) 50 mL (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Milton S. Hershey Medical Center
- Primary completion
- May 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Ascending Sinotubular Junction Measurement |
246.4; 287.5 | — |
| PRIMARY Descending Thoracic Aorta Measurement |
261.9; 312.8 | — |
| PRIMARY Celiac Measurement |
243.8; 329.5 | — |
| PRIMARY Burfication Measurement |
336.2; 321.2 | — |
| PRIMARY Right Common Femoral Artery Measurement |
314.5 | — |
| PRIMARY Left Common Femoral Artery Measurement |
309.5 | — |
| PRIMARY CTA Vessel Opacification Grading 1 |
4; 4.3 | — |
| PRIMARY CTA Vessel Opacification Grading 2 |
4.2; 4.4 | — |
Summary
The purpose of the study is to determine if the dose of contrast (Omnipaque) administered for Computed Tomography Arteriograms (CTA) can be reduced without degradation of image quality. The hypothesis is that there is no difference in image quality using ultra-low dose contrast in CTA exams compared to routine, standard of care dose exams.
Eligibility Criteria
Inclusion Criteria
- Any adult patient scheduled for a computed tomographic arteriogram (CTA) of the chest or chest, abdomen and pelvis who had undergone a prior CTA performed with the standard contrast dose (100 mL) at this institution will be included in the study
- The follow-up scan will be routine standard of care, no emergency imaging patient will be approached for this research
Exclusion Criteria
- Patients with no prior CTA imaging for comparison
- Any pediatric patient (age 40
- Inability to follow instructions
- Allergy to intravenous contrast
- GFR less than 30 mL/min/1.73 m2
Data sourced from ClinicalTrials.gov (NCT02669784). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.