N/A
N=20
Medium Chain Triglycerides and Aerobic Exercise on Ketone Production in Women With or Without Prediabetes
Prediabetic State
Bottom Line
View on ClinicalTrials.gov: NCT02678390 ↗Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Apr 2020
Primary outcome: Primary: Plasma Ketone Concentrations — -52; 12; 493; 627 (µmol/h)/L
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- MCT (Dietary_supplement); MCT+ aerobic exercise (Dietary_supplement); Aerobic exercise (Dietary_supplement); Control day (Dietary_supplement)
- Age
- Adult, Older Adult · 60+ yrs
- Sex
- Female
- Sponsor
- Université de Sherbrooke
- Primary completion
- Sep 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Plasma Ketone Concentrations |
-52; 12; 493; 627; 122; 23 | — |
| SECONDARY Plasma Glucose Concentrations |
7.6; 11.0; 7.3; 11.6; 7.6; 10.4 | — |
| SECONDARY Plasma Triglyceride Concentrations |
3.6; 3.8; 3.9; 3.5; 4.0; 3.7 | — |
| SECONDARY Plasma Free Fatty Acid Concentrations |
1.3; 1.3; 1.3; 1.5; 1.3; 1.4 | — |
| SECONDARY Plasma Insulin Concentrations |
0.9; 0.8; 0.8; 0.8; 0.8; 0.7 | — |
Summary
The aim of this study is to compare the effect on ketone production of dietary an MCT supplement combined or not with physical exercise in two groups of women (N=10/group), healthy adults and patients with prediabetes. After an evaluation of the metabolism (a 4-hour visit with multiple blood samples) at the beginning of the study, all the participants are taken for one-week the MCT supplement alone follow by a one-week period of taking the MCT supplement in combination with physical exercise. At the end of each period of time, the 4-hour visit for the evaluation of the metabolism is repeated.
Eligibility Criteria
Inclusion Criteria
- Healthy women group: fasting blood glucose < 6.1 mmol/L and HbA1c < 6.0 %.
- Women with prediabetes: fasting blood glucose between 6.1 and 6.9 mmol/L and HbA1c between 6.0 and 6.4 %
Exclusion Criteria
- Structured physical activity (more than 2 times per week)
- Inability to practice physical exercise
- Diabetes (fasting glucose ≥ 7.0mmol/L or HbA1c ≥ 6.5%)
- Uncontrolled dyslipidemia or hypertension
- Use of medications known to affect the metabolism of lipids and carbohydrates (steroids, beta-blockers, diuretics, insulin sensitizers, etc.)
- Severe infections or inflammations
Data sourced from ClinicalTrials.gov (NCT02678390). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.