N/A N=10 Basic Science

Comparing the Ketogenic Effect of Coconut Oil and Different MCTs

Healthy Adults

Bottom Line

View on ClinicalTrials.gov: NCT02679222 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Apr 2020

Primary outcome: Primary: Plasma Ketone Concentrations — 69; 294; 109; 363 µmol/L

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Coconut oil (Dietary_supplement); Coconut oil + MCT (Dietary_supplement); MCT (Dietary_supplement); Coconut oil + tricaprylin (Dietary_supplement); Tricaprylin (Dietary_supplement); Tricaprin (Dietary_supplement); Control (Dietary_supplement)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Université de Sherbrooke
Primary completion: Dec 2016

Outcome Measures

Outcome	Result	p-value
PRIMARY Plasma Ketone Concentrations	69; 294; 109; 363; 107; 141	—
SECONDARY Plasma Acetoacetate/Beta-hydroxybutyrate Ratio	7.7; 6.9; 7.7; 5.9; 9.5; 8.4	—

Summary

The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults. Each oil are evaluated individually or in combination over a 8h-period during which repeated blood sampling is performed.

Eligibility Criteria

Inclusion Criteria

Healthy adult over 18 y old.

Exclusion Criteria

Fasting plasma glucose ≥7.0 mM (diabetics or pre-diabetics);
Smoking
Clinically-significant gastro-intestinal disease/conditions.
Clinically-significant liver disease/dysfunction.
Clinically-significant cardiac disease/conditions.
Clinically-significant abnormal coagulation.
Taking a medication that could affect lipid and glucose metabolism
Hypertension
Pregnancy or breastfeeding
Exercising more than 3 times a week

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02679222). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.