N/A N=23 Randomized Double-blind Treatment

Clinical Outcomes of Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine

Anesthesia

Bottom Line

View on ClinicalTrials.gov: NCT02708433 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Sep 2018

Primary outcome: Primary: Mean Time to Pulpal Response After Mandibular Molar Anesthesia — 99; 98 Minutes — p=0.74

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Lidocaine (Drug)
Age: Adult · 18+ yrs
Sex: All
Sponsor: University of North Carolina, Chapel Hill
Primary completion: Aug 2017

Outcome Measures

Outcome	Result	p-value
PRIMARY Mean Time to Pulpal Response After Mandibular Molar Anesthesia	99; 98	0.74
PRIMARY Mean Time to Pulpal Response After Mandibular Canine Anesthesia	82; 85	0.5

Summary

Anecdotal data suggest that the buffered form of the local anesthetic is more potent at equal dosages, and a lower dosage of the drug might be used with an effect equal to higher dosage not buffered. Clinical data are needed to confirm these anecdotal data. No data exist comparing buffered local anesthetics at lower drug concentrations to current dosages commonly used in dental and oral surgical procedures

Eligibility Criteria

Inclusion Criteria

Age 18-30 years, ASA I

Exclusion Criteria

Allergy to lidocaine class of anesthetic drugs Local anesthetic drug use in past week Current symptoms teeth or oral mucosa

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02708433). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.