N/A
Completed N=23
Clinical Outcomes of Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine
Anesthesia
Source: ClinicalTrials.gov NCT02708433 ↗
Enrolled (actual)
23
Serious AEs
0.0%
Results posted
Sep 2018
Primary outcomePrimary: Mean Time to Pulpal Response After Mandibular Molar Anesthesia — 99; 98 Minutes — p=0.74
Summary
Anecdotal data suggest that the buffered form of the local anesthetic is more potent at equal dosages, and a lower dosage of the drug might be used with an effect equal to higher dosage not buffered. Clinical data are needed to confirm these anecdotal data. No data exist comparing buffered local anesthetics at lower drug concentrations to current dosages commonly used in dental and oral surgical procedures
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Time to Pulpal Response After Mandibular Molar Anesthesia |
99; 98 | 0.74 |
| PRIMARY Mean Time to Pulpal Response After Mandibular Canine Anesthesia |
82; 85 | 0.5 |
Eligibility Criteria
Inclusion Criteria
- Age 18-30 years, ASA I
Exclusion Criteria
- Allergy to lidocaine class of anesthetic drugs Local anesthetic drug use in past week Current symptoms teeth or oral mucosa
Data sourced from ClinicalTrials.gov (NCT02708433). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.