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N/A N=1,139 Randomized Prevention

Working to Increase Stability Through Exercise

Fractures, Bone · Serious Fall-related Injuries

Enrolled (actual)
1,139
Serious AEs
21.2%
Results posted
Feb 2025
Primary outcome: Primary: Number of Participants Experiencing a Serious Fall-Related Injury (SFI) — 186; 166 Participants — p=0.43

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Enhanced Usual Care plus Exercise Coaching (Behavioral)
Age
Older Adult · 65+ yrs
Sex
All
Sponsor
Milton S. Hershey Medical Center
Primary completion
Dec 2021

Outcome Measures

OutcomeResultp-value
PRIMARY
Number of Participants Experiencing a Serious Fall-Related Injury (SFI)
186; 166 0.43
SECONDARY
Number of Falls and Falls-related Injuries Using the Behavioral Risk Factor Surveillance System (BRFSS)
0.87; 0.84 0.50
SECONDARY
Percentage of Participants With Excellent/Very Good Health Using the Patient Reported Outcomes Measurement Information System (PROMIS)
52.2; 54.3 0.30
SECONDARY
Assessment of Fear of Falling Using the Falls Efficacy Scale International (FES-I)
11.65; 11.11 <0.01 sig
SECONDARY
Percentage of Participants Meeting Physical Activity Guidelines Using the National Health Interview Survey (NHIS)
50.7; 50.9 0.73
SECONDARY
Assessment of Physical Function Using PROMIS
9.00; 8.77 0.27
SECONDARY
Assessment of Depression Using PROMIS
5.62; 5.52 0.37
SECONDARY
Assessment of Anxiety Using PROMIS
6.21; 6.07 0.26
SECONDARY
UCLA Brief Loneliness Scale
4.19; 4.12 0.39

Summary

The investigators propose a 36-month multi-center randomized effectiveness trial to compare the impact of an Enhanced Usual Care (Control) intervention, with Exercise Coaching (Exercise), on Serious Fall-Related Injuries (SFI) in patients with a previous fragility fracture (FF). The investigators will also examine the impact of the intervention on several secondary outcomes like: loneliness, physical function, and bone strength. The investigators will do this by following a Pragmatic trial design: 1) limiting exclusions to increase representativeness, 2) limiting research contacts (average 30 min/year) and 3) limiting measures to those practicable for use in usual care.

Eligibility Criteria

Inclusion Criteria

  • ≥ 65 years old
  • Previous Fragility Fracture (FF) in past 10 years.
  • Able to speak and understand English.
  • Participants will need to be willing to try exercising and agree to annual follow-up measurements.

Exclusion Criteria

If the answer to the following questions are "yes", the investigators will exclude the participant from the study Do you feel pain in your chest, neck, jaw, or arms at rest, during your daily activities of living, OR when you do physical activity? Have you ever been told by a health professional that you should not exercise OR exercise only when supervised by a professional?

If the answer to the following questions are "yes", the investigators will contact physician for permission Do you experience unpleasant awareness of a forceful or rapid heart rate? Do you experience unreasonable breathlessness? Do you experience dizziness fainting or blackouts? Do you experience ankle swelling? Do you have burning or cramping sensation on your lower legs when walking short distances? Do you have diabetes?

Has a doctor, nurse or health professional ever told you that you had any of the following? Weak or failing kidneys? A heart attack, also called a myocardial infarction? Angina or coronary heart disease? A stroke? Any kind of heart condition or heart disease other than the ones I just asked about?

Unable to obtain primary care provider consent (if required based on questions above)

If the participant answer "NO" to the following question: Is it ok if the investigators contact your primary care provider?

If the participant answer "YES" to the following question:Have you been hospitalized for psychiatric problem in past year?

If the participant is planning on moving out of the area in the next 36 months

If currently participates in the Band Together exercise program

Positive Callahan cognition screener: If participant fails 2 questions, research coordinator will explain study in detail and ask read-back questions. The participant will be excluded if failed read-back.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02714257). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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