Phase 3
Completed N=102
Surgical Site Infections After Liver Transplantation Based on Perioperative Antibiotics
Source: ClinicalTrials.gov NCT02717273 ↗Enrolled (actual)
102
Serious AEs
0.0%
Results posted
Jul 2018
Primary outcomePrimary: Number of Subjects With Development of Surgical Site Infections — 9; 13 Participants
◆ Published Evidence
Established
20citations · ~3 / year
Perioperative antibiotics for preventing post-surgical site infections in solid organ transplant recipients.
Summary
This study will be to prospectively determine differences in Surgical Site Infection (SSI) if a prolonged course of post-operative antibiotics are used following liver transplantation.
Linked Publications
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Perioperative antibiotics for preventing post-surgical site infections in solid organ transplant recipients.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Subjects With Development of Surgical Site Infections |
9; 13 | — |
| SECONDARY Number of Subjects With Post-operative Fever |
6; 7 | — |
| SECONDARY Number of Subjects With Elevated White Blood Count (WBC) |
42; 41 | — |
| SECONDARY Number of Subjects With Nosocomial Infection |
8; 11 | — |
| SECONDARY Length of Hospital Stay |
7.5; 7.5 | — |
| SECONDARY Number of Subjects With Graft Loss |
7; 6 | — |
| SECONDARY Number of Subjects With Mortality |
1; 1 | — |
Eligibility Criteria
Inclusion Criteria
- All patients ≥ 18 years of age.
- Eligible for liver transplantation by UVA standard protocol.
- First-time transplantation.
- No active infections - requiring antibiotics - excluding antifungals.
Exclusion Criteria
- All patients < 18 years of age.
- Previous liver transplantation.
- Active infections - requiring antibiotics.
- Allergy to all standard peri-operative antibiotics (piperacillin/tazobactam or UVA standard alternatives for Penicillin allergic patients: ciprofloxacin and vancomycin).
Data sourced from ClinicalTrials.gov (NCT02717273) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.