N/A
Completed N=18
Phenolic-rich Oats and Artery Improvement
Healthy
Source: ClinicalTrials.gov NCT02731755 ↗
Enrolled (actual)
18
Serious AEs
0.0%
Results posted
Nov 2019
Primary outcomePrimary: Flow Mediated Dilatation — 4.4; 3.9; 3.4; 4.4 metre — p=0.5
Summary
In this proposed human trial, the investigators aim to establish whether consumption of one portion of phenolic acid-rich oats leads to acute improvements (i.e. 1-24h post-intake) in markers of cardiovascular disease risk relative to an energy matched control intervention in healthy men with high-normal to mildly elevated blood pressure.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Flow Mediated Dilatation |
4.4; 3.9; 3.4; 4.4; 4.4; 3.6 | 0.5 |
| SECONDARY Laser Doppler Iontophoresis |
538.2; 465; 681.8; 463.7; 381.3; 315 | 0.04 sig |
| SECONDARY Phenolic Acids Metabolites - Ferulic Acid |
10.6; 0.4; 33.9; 9; 153.5; 10.3 | 0.9 |
| SECONDARY Plasma Nitric Oxide Analysis |
— | — |
| SECONDARY NADPH Oxidase Activity in Neutrophil Blood Cells |
55.7; 58.6; 43.6; 47.9; 63.6; 61.6 | 0.7 |
| SECONDARY Plasma Glucose |
— | — |
| SECONDARY Plasma Insulin |
— | — |
| SECONDARY Renin Activity |
— | — |
Eligibility Criteria
Inclusion Criteria
- Above average blood pressure (i.e. systolic 120-159 mmHg and diastolic 75-99 mmHg)
Exclusion Criteria
- Abnormal biochemical, haematological results as assessed at health screening
- Hypertension (i.e. systolic/diastolic blood pressure ≥160/100 mm Hg) BMI >35
- Current smoker or ex-smoker ceasing 3 x 20 min aerobic exercise/week)
- Consumption of ≥21 units of alcohol/week
- Small veins not allowing cannulation
Data sourced from ClinicalTrials.gov (NCT02731755). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.