Phase 2 N=80 Randomized Quadruple-blind Treatment

Clonidine Added Lidocaine in Intraocular Pressure and Hemodynamics Ocular in Sub-Tenon's and Peribulbar Anesthesia

Anesthesia

Bottom Line

View on ClinicalTrials.gov: NCT02733757 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2020

Primary outcome: Primary: Intraocular Pressure (IOP) — 18; 16; 19; 16 mmHg

Study Design & Population

Study type: Interventional
Phase: Phase 2
Interventions: Clonidine (Drug)
Age: Adult, Older Adult · 30+ yrs
Sex: All
Sponsor: Federal University of Minas Gerais
Primary completion: Oct 2015

Outcome Measures

Outcome	Result	p-value
PRIMARY Intraocular Pressure (IOP)	18; 16; 19; 16	—

Summary

Regional anesthesia in orbit can reduce ocular blood flow, increase in intraocular pressure (IOP) or the pharmacological action of local anesthetics. This study was conduced to evaluate the effects of clonidine added to lidocaine in IOP, ocular perfusion pressure (PPO) and ocular pulse amplitude (OPA) in patients undergoing cataract surgery under sub-Tenon's and peribulbar anesthesia.

Eligibility Criteria

Inclusion Criteria

Adults between 30 and 86 years old
Both genders
Physical status ASA (American Society of Anesthesiologists) I and II
Cooperative patients undergoing cataract surgery by phacoemulsification

Exclusion Criteria

Patients with communication difficulties
Allergic to any medication protocol
Chronic therapy with clonidine
In use of antihypertensive medication
Diabetes
Glaucoma
Previous surgery in the same eye
Abnormalities in coagulation

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Data sourced from ClinicalTrials.gov (NCT02733757). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.