N/A N=24 Randomized Double-blind Treatment

Clinical Outcomes Maxilla: Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine

Anesthesia

Bottom Line

View on ClinicalTrials.gov: NCT02747186 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2018

Primary outcome: Primary: Mean Time to Pulpal Response After Maxillary Molar Anesthesia — 98.8; 84.5 minutes

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Lidocaine (Drug)
Age: Adult · 18+ yrs
Sex: All
Sponsor: University of North Carolina, Chapel Hill
Primary completion: Dec 2017

Outcome Measures

Outcome	Result	p-value
PRIMARY Mean Time to Pulpal Response After Maxillary Molar Anesthesia	98.8; 84.5	—
PRIMARY Mean Time to Pulpal Response After Maxillary Canine Anesthesia	77.1; 70.9	—

Summary

Anecdotal data suggest that the buffered form of the local anesthetic is more potent at equal dosages, and a lower dosage of the buffered drug might be used with an effect equal to higher dosage not buffered. Clinical data are needed to confirm these anecdotal data. No published data exist comparing buffered local anesthetics at lower drug concentrations to current dosages commonly used in dental and oral surgical procedures

Eligibility Criteria

Inclusion Criteria

American Society of Anesthesiologists Risk Classification I Willingness to participate in two sessions

Exclusion Criteria

Allergy to lidocaine class of anesthetic drugs Local anesthetic drug use in past week Current symptoms teeth or oral mucosa

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Data sourced from ClinicalTrials.gov (NCT02747186). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.