Phase 4
Completed N=122
Isopropyl Alcohol vs Ondansetron for Nausea in the Emergency Department
Source: ClinicalTrials.gov NCT02760069 ↗Enrolled (actual)
122
Serious AEs
0.0%
Results posted
Jul 2020
Primary outcomePrimary: Nausea 100 mm Visual Analogue Scale (VAS) — 23; 19; 42 units on a scale
◆ Published Evidence
Established
39citations · ~5 / year
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial.
Summary
This study will compare the efficacy of isopropyl alcohol and conventional anti-emetics with three study arms: (1) inhaled isopropyl alcohol plus oral ondansetron; (2) inhaled isopropyl alcohol plus oral placebo; (3) inhaled placebo plus oral ondansetron.
Linked Publications
-
Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Nausea 100 mm Visual Analogue Scale (VAS) |
23; 19; 42 | — |
| SECONDARY Number of Participants Who Required Rescue Anti-emetics |
11; 10; 18 | — |
Eligibility Criteria
Inclusion Criteria
- ages 18 and older
- complaint of nausea and/or vomiting reported at 3 or above on verbal numerical rating scale at the time of triage
Exclusion Criteria
- allergy to isopropyl alcohol or ondansetron
- inability to breathe through nose (e.g., recent upper respiratory infection)
- intake of cefoperazone, disulfiram, or metronidazole within the last 24 hours
- mental status precluding informed consent including intoxication
- known QT-prolongation
- clinical suspicion for serotonin syndrome
- intravenous catheter in place prior to study start
- medications administered since patient arrival (e.g., in triage)
Data sourced from ClinicalTrials.gov (NCT02760069) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.