N/A N=78 Randomized Single-blind Prevention

Aerobic Exercise and Cognitive Training in Older Adults

Sedentary Lifestyle

Bottom Line

View on ClinicalTrials.gov: NCT02787655 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2020

Primary outcome: Primary: Change Executive Language Functions (Category Verbal Fluency) — 5; -1 Number of Fluent Words within 60 seconds

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Aerobic exercise + Cognitive Training Group (Behavioral); Cognitive training Only (Behavioral)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: VA Office of Research and Development
Primary completion: Apr 2019

Outcome Measures

Outcome	Result	p-value
PRIMARY Change Executive Language Functions (Category Verbal Fluency)	5; -1	—

Summary

The purpose of this study is to examine the impact of a combined cognitive training and aerobic exercise intervention in sedentary older adults. It is hypothesized that the aerobic exercise will potentiate and increase the generalizability of the cognitive training. Importantly, this study will focus on older adults at-risk for mobility disability. This area is of particular importance considering a large percentage of adults are entering old age and therefore likely to suffer from age-related cognitive decline and mobility disability. To address the investigators' research question 60 adults (age 18-89) will be randomized to one of two 12 week intervention groups: 1) Cognitive Training alone (CT) or 2) Aerobic Exercise + Cognitive Training (AE+CT). The aerobic exercise arm of the study will follow the same format shown to improve a broad range of executive functions in older adults in previous research. The cognitive training arm will consists of a popular commercially-available brain fitness program that has demonstrated specific cognitive improvements and high adherence.

Eligibility Criteria

Inclusion Criteria

Right handed
English speaking
Aged 18 to 89
Sedentary as defined by < 120 min/week of aerobic exercise over prior 3 months
Non-demented (MMSE 24)

Exclusion Criteria

Severe diabetes requiring insulin
Cognitive-executive function deficit (MoCA < 26)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02787655). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.