N/A
N=30
Exercise Prehab in Older Adults With Hematologic Malignancies
Hematopoietic and Lymphoid Cell Neoplasm
Bottom Line
View on ClinicalTrials.gov: NCT02791737 ↗Enrolled (actual)
30
Serious AEs
0.0%
Results posted
Jun 2025
Primary outcome: Primary: Number of Patients With Adverse Events (AE), Graded According to Common Terminology Criteria for Adverse Events Version 5.0 — 0 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Exercise Intervention (Behavioral); Laboratory Biomarker Analysis (Other); Physical Therapy (Procedure); Quality-of-Life Assessment (Other); Questionnaire Administration (Other)
- Age
- Adult, Older Adult · 60+ yrs
- Sex
- All
- Sponsor
- Ohio State University Comprehensive Cancer Center
- Primary completion
- Jul 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Patients With Adverse Events (AE), Graded According to Common Terminology Criteria for Adverse Events Version 5.0 |
— | — |
| PRIMARY Percentage of Eligible Patients Completing the OEP |
66.7 | — |
| SECONDARY Biomarker Expression Levels |
1.26; -0.19; 0.15; 0.62; -0.05; 0.20 | — |
| SECONDARY Change in Geriatric Assessment (GA) Measured Using The Cancer and Aging Research Group (CARG) Geriatric Assessment (G)A-patient Reported Karnofsky Performance Status (KPS) for Patients Undergoing Transplant |
80; 85; 90 | — |
| SECONDARY Change in Geriatric Assessment (GA) Measured Using the CARG GA-patient Reported Karnofsky Performance Status (KPS) |
80; 90; 90 | — |
| SECONDARY Health Related Quality of Life (HRQL) Measured Using the PROMIS |
32.4; 34.9; 36.2 | — |
| SECONDARY Change in HRQL Measured Using the PROMIS for Patients Undergoing Transplant |
34.9; 36.2; 34.9 | — |
| SECONDARY Number of Falls (Inpatient and Outpatient) |
3 | — |
| SECONDARY Change in Physical Performance Measured Using the Short Physical Performance Battery (SPPB) |
7; 11; 9 | — |
| SECONDARY Change in Physical Performance Measured Using the SPPB for Patients Undergoing Transplant |
8; 11.5; 10 | — |
| SECONDARY Percentage of Patients With Hospital Readmission for Patients Undergoing Transplant |
42.9 | — |
| SECONDARY Length of Inpatient Stays for Patients Undergoing Transplant |
18 | — |
Summary
This pilot trial studies a structured exercise program intervention in improving physical activity in older patients with hematologic malignancies undergoing cancer therapy. Patients with hematologic malignancies are at an increased risk of functional dependence and injury. Structured exercise programs, such as the Otago exercise programme (OEP), may improve balance, strength, and prevent fall-related injury in older patients with hematologic malignancies undergoing cancer therapy.
Eligibility Criteria
Inclusion Criteria
- Patients with hematologic malignancy receiving care (chemotherapy, immunotherapy, targeted agents, bone marrow transplant, or other) for their hematologic malignancy at the Ohio State University
- Impairments in physical function, as defined by a score < 9 on the SPPB pre-screen
- Medical clearance from an oncologist or primary care physician stating the participant is able to participate in an unsupervised, moderate-intensity physical activity program
- Ability to understand and the willingness to sign a written informed consent document
Exclusion Criteria
- Prisoners
- Any medical condition including, but not limited to, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness that would limit compliance with study procedures
Data sourced from ClinicalTrials.gov (NCT02791737). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.