Phase 2 Completed N=41 Basic Science

Effects of Sertraline on Brain Connectivity in Adolescents With OCD

OCD

Source: ClinicalTrials.gov NCT02797808 ↗

Enrolled (actual)

Serious AEs

2.4%

Results posted

Jan 2021

Primary outcomePrimary: CY-BOCS Total Score at 12-weeks — 14.1; 0 units on a scale

Summary

The investigators will examine how treatment with sertraline for 12 weeks impacts frontal-striatal-thalamic circuitry (FSTC) in this OCD sample.

Outcome Measures

Outcome	Result	p-value
PRIMARY CY-BOCS Total Score at 12-weeks	14.1; 0	—
PRIMARY Longitudinal 2-Group Resting State Functional Conectivity (RSFC) Analyses	0.15; 1.44; 1.89; 0.60; 1.46; 2.41	<0.0083 sig

Eligibility Criteria

Inclusion Criteria (OCD):

OCD as the primary Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) diagnosis based on the Anxiety Disorders Interview Schedule (ADIS) for DSM-IV, Child Version
Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) score of greater than 15

Exclusion Criteria (OCD):

lifetime diagnosis of bipolar disorder, schizophrenia, or substance abuse/dependence on ADIS
Intelligence Quotient (IQ) 2 selective serotonin reuptake inhibitor (SSRI) trials of adequate dose/duration
positive pregnancy test
history of seizure disorder or serious head injury

Inclusion Criteria (Controls):

Healthy 8-17 year olds

Exclusion criteria (controls):

No psychiatric diagnoses
No immediate family history of OCD

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02797808). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.