N/A
N=40
Clarithromycin as Adjuvant to Periodontal Debridement
Aggressive Periodontitis
Bottom Line
View on ClinicalTrials.gov: NCT02829983 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Oct 2017
Primary outcome: Primary: Clinical Attachment Level — 2.71; 3.03 milimeter
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Clarithromycin (Drug); Placebo (Drug); One-stage full-mouth ultrasonic debridement (FMUD) (Other)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
- Primary completion
- Aug 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Clinical Attachment Level |
2.71; 3.03 | — |
| SECONDARY Probing Depth |
2.53; 2.86 | — |
Summary
To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.
Eligibility Criteria
Inclusion Criteria
- diagnosis of Generalized Aggressive Periodontitis
- presence of ≥20 teeth
- presence of ≥ 6 sites presenting probing depth (PD) ≥5mm with bleeding on probing (BOP) and ≥2 sites with PD ≥7mm (including incisors and first molars, in addition to two other non-contiguous teeth between them)
- good general health
- <35 years of age
- agree to participate in the study and sign a written consent
Exclusion Criteria
- pregnant or lactating
- suffering from any other systemic disease (e.g. cardiovascular, diabetes, blood dyscrasias, immunodeficiency, etc) which could alter the course of periodontal disease
- received antimicrobials in the previous 6 months
- taking long-term anti-inflammatory drugs
- received a course of periodontal treatment within the last 12 months
- smoked
Data sourced from ClinicalTrials.gov (NCT02829983). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.