N/A
N=34
Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels
Chronic Peridontitis Patients · Chronic Gingivitis · Healthy
Bottom Line
View on ClinicalTrials.gov: NCT02861937 ↗Enrolled (actual)
34
Serious AEs
0.0%
Results posted
Aug 2020
Primary outcome: Primary: Pocket Depth — 1.60; 2.50; 6.75 millimetres
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- non surgical periodontal therapy (Procedure)
- Age
- Adult · 20+ yrs
- Sex
- All
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
- Primary completion
- Sep 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pocket Depth |
1.60; 2.50; 6.75 | — |
| PRIMARY Gingival Index |
0.30; 1.71; 2.24 | — |
| PRIMARY Plaque Index |
0.31; 1.18; 2.14 | — |
| PRIMARY Relative Attachment Level: |
0; 0; 9.50 | — |
| PRIMARY Interleukin-21(IL-21) Cytokine Levels |
2245.900; 7215.341; 7390.167 | — |
Summary
Human IL-21 is present in gingival crevicular fluid in periodontal health, gingivitis and chronic periodontitis. A significant increase in the concentration of IL-21 in gingival crevicular fluid is observed with an increase in the amount of periodontal destruction. Non- surgical periodontal therapy aided in decrease of GCF IL-21 levels in clinical gingivitis and chronic periodontitis
Eligibility Criteria
Inclusion Criteria
- patients having more than or equal to 14 functional teeth, systemically healthy patients who had not received any form of surgical and non surgical periodontal therapy or received antibiotics or non-steroidal anti-inflammatory
Exclusion Criteria
- smokers pregnant females
Data sourced from ClinicalTrials.gov (NCT02861937). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.