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N/A Completed N=20 Randomized Double-blind Treatment

Immediate Effects of rTMS on Excitability of the Quadriceps With Knee Osteoarthritis

Osteoarthritis, Knee
Source: ClinicalTrials.gov NCT02881775 ↗
Enrolled (actual)
20
Serious AEs
0.0%
Results posted
May 2019
Primary outcomePrimary: Quadriceps Central Activation Ratio (CAR) — 86.3554; 86.1983; -1.2496; -1.2670 % activation — p=.9994

Summary

The purpose of the study is to identify things that influence the ability to "turn on" the thigh muscle (quadriceps). The thigh muscle tends to be under active with knee osteoarthritis, which may make it difficult to strengthen the muscle. The investigators are also testing a new technology called repetitive transcranial magnetic stimulation (rTMS) to determine whether it may help "turn up" activity in the under active thigh muscle immediately after its application. rTMS uses a targeted pulsed magnetic field, similar to what is used in an MRI (magnetic resonance imaging) machine to send an electrical signal from the brain to the thigh muscle.

Outcome Measures

OutcomeResultp-value
PRIMARY
Quadriceps Central Activation Ratio (CAR)		 86.3554; 86.1983; -1.2496; -1.2670 .9994
PRIMARY
Quadriceps Maximal Voluntary Isometric Contraction (MVIC)		 129.46; 129.09; -6.3473; -6.1643 .9768
SECONDARY
Numeric Pain Rating Scale (NPRS) Score		 3.25; 3.000; -.625; -.1570 0.4440
SECONDARY
Pressure Pain Threshold (PPT) - Medial Knee		 402.41; 419.21; 21.8583; 4.3548 .6608
SECONDARY
Timed Up & Go (TUG)		 8.3919; 8.3056; -.08021; -.00542 .7706
SECONDARY
Active Motor Threshold Motor Evoked Potential (AMT-MEP)		 .1387; .1434; -.00007; -.01441 .3665
SECONDARY
Short Interval Cortical Inhibition (SICI)		 .5140; .5996; -.02588; -.1151 .3889
SECONDARY
Intra Cortical Facilitation (ICF)		 1.193; .904; -.0354; .03042 .2192

Eligibility Criteria

Inclusion Criteria

  • symptomatic knee osteoarthritis primarily involving one leg based on Western Ontario and McMaster Universities Arthritis Index (WOMAC) function subscale score > 10 (out of 100 points, indicating most dysfunction)
  • diagnosis of knee osteoarthritis
  • opposite knee with WOMAC pain score ≤ 5.
  • opposite knee does not have a diagnosis of knee osteoarthritis

Exclusion Criteria

  • conditions affecting the leg other than osteoarthritis
  • low blood pressure ( 35
  • severe arthritis in both knees
  • history of leg or back surgery in the past year or knee replacement surgery;
  • injection in the knee joint in the past 4 weeks
  • requires an assistive device to walk
  • any contraindications for TMS or rTMS (seizures, metal implants in head, brain related conditions, brain injury, drug or alcohol withdrawal)
  • medications that lower seizure threshold
  • history of fainting spells (syncope) or low blood pressure
  • sleep deprived
  • inability to understand and repeat back directions regarding the study
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02881775). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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