N/A N=90 Randomized Supportive Care

The Impact of IV Acetaminophen on Pain After Appendectomy for Perforated Appendicitis

Perforated Appendicitis

Bottom Line

View on ClinicalTrials.gov: NCT02881996 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jan 2021

Primary outcome: Primary: Time Until PCA Discontinued After the Operation — 76.4; 86.7 hours

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: IV tylenol (Drug); No IV tylenol (Drug); Ketorolac (Drug)
Age: Pediatric · 2+ yrs
Sex: All
Sponsor: Children's Mercy Hospital Kansas City
Primary completion: Jun 2016

Outcome Measures

Outcome	Result	p-value
PRIMARY Time Until PCA Discontinued After the Operation	76.4; 86.7	—
SECONDARY Postoperative Duration of Hospital Stay	3.9; 4.5	—

Summary

The objective of this study is to evaluate two standard post-operative pain regimens routinely used after laparoscopic appendectomy for perforated appendicitis. The investigators hypothesize that the use of intravenous (IV) acetaminophen in addition to IV ketorolac with narcotic pain pump will decrease time to transition off patient/nurse controlled analgesia (PCA) to oral pain medications.

Eligibility Criteria

Inclusion Criteria

All patients ages 2-17 years old undergoing laparoscopic appendectomy at CMH found to have perforated appendicitis.

Exclusion Criteria

Non-perforated appendicitis
Normal appendix at the time of operation or other associated conditions causing abdominal pain
Patients with history of chronic pain
Known underlying liver disorders
Known allergy to pain medication in protocol
Non-English speaking

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02881996). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.