N/A
Completed N=9
Impact of Extra Virgin Olive Oil Oleocanthal Content on Platelet Reactivity
Source: ClinicalTrials.gov NCT02902913 ↗Enrolled (actual)
9
Serious AEs
0.0%
Results posted
Nov 2019
Primary outcomePrimary: Optical Platelet Aggregometry — -13; -35; 7; -57.5 percentage of maximal aggregation
Summary
Data from limited dietary intervention trials suggest that the cardiovascular health benefit of extra virgin olive oil (EVOO) may increase with phenolic content. However, while EVOOs contain an array of bioactive compounds, little information exists regarding the physiological effects of specific chemical species. Among the EVOO-derived phenolics with demonstrated anti-inflammatory effects in animal and in vitro models is oleocanthal, an inhibitor of cyclooxygenase (COX). The current study compared the impact of acute intake (40 mL) of EVOO on platelet reactivity in healthy adult males (n=9). The volunteers were randomly assigned to consume three EVOOs in a double-blind controlled trial. The EVOO were characterized and chosen for equivalency in their total phenolic content and fatty acid profiles, but differing in their oleocanthal to oleacein ratio.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Optical Platelet Aggregometry |
-13; -35; 7; -57.5 | — |
| SECONDARY Activated Platelet Oxylipin Production |
-0.02; -0.45; -0.17; -0.66 | — |
Eligibility Criteria
Inclusion Criteria
- Willing and able to comply with study protocols
- Willing to drink 2 tablespoons of olive oil
- BMI 18.5 to 30 kg/m2
- Weight ≥ 110 pounds
Exclusion Criteria
- Adults who are not able to consent
- BMI ≥ 31 kg/m2
- Under current medical supervision
- Self-reported daily use of drugs that are known to affect platelet function, such as aspirin, Excedrin, and NSAIDS
- Ibuprofen intolerance or allergy
- Cannot speak English
- Allergy to olives or olive oil
- Vegetarian, Vegan, food faddists, individuals using non-traditional diets, on a weight loss diet or individual following diets with significant deviations from the average diet of the general population.
- A history of cardiovascular disease, stroke, cancer, renal, hepatic, or thyroid disease, GI tract disorders, previous GI surgery
- Currently taking prescription drugs or supplements
- Indications of substance or alcohol abuse within the last 3 years
- Not willing to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements.
- Not willing to refrain from olive oil consumption.
- Blood Pressure ≥ 140/90 mmHg
- Self-reported malabsorption
- Metabolic panel results or complete blood counts that are outside of the normal reference range.
- Screening LDL ≥ 190 mg/dl for those who have 0 - 1 major risk factors apart from LDL cholesterol [(i.e. family history of premature coronary artery disease (male first degree relative < 55 years; CHD in female first degree relative < 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL].
- Screening LDL ≥ 160 mg/dl for those who have 2 major risk factors apart from LDL cholesterol [(i.e. family history of premature coronary artery disease (male first degree relative < 55 years; CHD in female first degree relative < 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL].
- Screening LDL ≥ than 130 mg/dl for those who have 2 major risk factors apart from LDL cholesterol ((i.e. family history of premature coronary artery disease (male first degree relative < 55 years; CHD in female first degree relative < 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL), and a Framingham 10 - year Risk Score 10 - 20 % (using NCEP calculator).
- Current enrollee in a clinical research study.
- Individuals with blood clotting or platelet defect disorders
Data sourced from ClinicalTrials.gov (NCT02902913). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.