N/A
N=99
Platelet Function in Resuscitated Patients
Acute ST Segment Elevation Myocardial Infarction
Bottom Line
View on ClinicalTrials.gov: NCT02914795 ↗Enrolled (actual)
99
Serious AEs
0.0%
Results posted
Dec 2020
Primary outcome: Primary: Platelet Inhibition Measured With Optical Aggregometry — 109; 253.8 AU*min
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- diagnostic analysis of platelet function (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Medical University of Graz
- Primary completion
- Jul 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Platelet Inhibition Measured With Optical Aggregometry |
109; 253.8 | — |
| SECONDARY Number of Participants With Cumulative Clinical Endpoint of Death and Stent Thrombosis |
0; 3 | — |
Summary
Approx. 65% of resuscitated patients at the intensive care unit for internal medicine are due to myocardial infarction. Almost all patients are initially diagnosed and treated in the cath lab. Therapy usually consists of one or more stent implantations. After implantation of a coronary stent, dual platelet inhibition is necessary for 12 months. Insufficient platelet inhibition causes an pronounced increase in risk of stent thrombosis. Therefore, knowledge of the individual platelet function is valuable.
Several factors potentially promote a delayed or reduced mode of action of platelet function inhibitors in resuscitated patients:
1. oral administration is impossible and medication needs to be administered via a gastric line.
2. gastric absorption is delayed after resuscitation
3. according to current guidelines patients are treated with therapeutic hypothermia. Including the time of rewarming cooling period is ~48h
Eligibility Criteria
Inclusion Criteria
- Myocardial infarction
- dual platelet inhibition
- resuscitation
- therapeutic hypothermia
Exclusion Criteria
- none
Data sourced from ClinicalTrials.gov (NCT02914795). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.