N/A Completed N=99

Platelet Function in Resuscitated Patients

Acute ST Segment Elevation Myocardial Infarction

Source: ClinicalTrials.gov NCT02914795 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2020

Primary outcomePrimary: Platelet Inhibition Measured With Optical Aggregometry — 109; 253.8 AU*min

Summary

Approx. 65% of resuscitated patients at the intensive care unit for internal medicine are due to myocardial infarction. Almost all patients are initially diagnosed and treated in the cath lab. Therapy usually consists of one or more stent implantations. After implantation of a coronary stent, dual platelet inhibition is necessary for 12 months. Insufficient platelet inhibition causes an pronounced increase in risk of stent thrombosis. Therefore, knowledge of the individual platelet function is valuable. Several factors potentially promote a delayed or reduced mode of action of platelet function inhibitors in resuscitated patients: 1. oral administration is impossible and medication needs to be administered via a gastric line. 2. gastric absorption is delayed after resuscitation 3. according to current guidelines patients are treated with therapeutic hypothermia. Including the time of rewarming cooling period is ~48h

Outcome Measures

Outcome	Result	p-value
PRIMARY Platelet Inhibition Measured With Optical Aggregometry	109; 253.8	—
SECONDARY Number of Participants With Cumulative Clinical Endpoint of Death and Stent Thrombosis	0; 3	—

Eligibility Criteria

Inclusion Criteria

Myocardial infarction
dual platelet inhibition
resuscitation
therapeutic hypothermia

Exclusion Criteria

none

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02914795). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.