N/A
N=49
Physiology of Lung Collapse Under One-Lung Ventilation: Underlying Mechanisms
Lung Collapse · One-Lung Ventilation · Thoracic Surgery · Video-Assisted
Bottom Line
View on ClinicalTrials.gov: NCT02919267 ↗Enrolled (actual)
49
Serious AEs
0.0%
Results posted
Jul 2019
Primary outcome: Primary: Quantification of Gas Volume Coming From Ambient Air Towards the Alveoli Space of the Non-ventilated Lung During OLV With the Use of DLT and BB. — 504; 630 milliliters (mL)
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Double lumen tube (Device); Bronchial blocker (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Laval University
- Primary completion
- Dec 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Quantification of Gas Volume Coming From Ambient Air Towards the Alveoli Space of the Non-ventilated Lung During OLV With the Use of DLT and BB. |
504; 630 | — |
| SECONDARY Measurement of Intra-pulmonary Pressure in the Non-ventilated Lung With the Use of DLT and BB |
0; 0; -1.1; -0.7; -2.4; -2.6 | — |
Summary
Lung isolation technique and one-lung ventilation (OLV) are the mainstays of thoracic anesthesia. Two principal lung isolation techniques are mainly use by clinicians, the double lumen tubes (DLT) and the bronchial blockers (BB). The physiology of lung collapse during OLV is not well described in the literature. Few publications characterized scant aspects of lung collapse, only with the use of DLT and sometime in experimental animals. Two phases of lung collapse have been described. The first phase is a quick and partial secondary to the intrinsic recoil of the lung. The second phase is the reabsorption of gas contained in the alveoli by the capillary bed. The investigators plan to describe the physiology of the second phase of lung deflation using of DLT or BB, in a human clinical context.
Eligibility Criteria
Inclusion Criteria
- elective unilateral lung resection (anatomical segmentectomy, lobectomy or pneumonectomy) for lung cancer
Exclusion Criteria
- anticipated difficult mask ventilation or intubation
- pleural pathology
- previous thoracic surgery
- previous sternotomy
- previous chemotherapy or chest radiotherapy
- severe COPD or asthma (FEV1 ≤ 50%)
- active or chronic pulmonary infection
- endobronchial mass
- tracheostomy
Post randomisation exclusion criteria :
- severe desaturation before or during the observation period
- any clinical situation precluding the use of one of the lung isolation device
- air leak at the level of bronchial isolation
Data sourced from ClinicalTrials.gov (NCT02919267). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.