N/A
N=31
TMS Modulation of Insula-related Brain Networks.02
Healthy Subjects
Bottom Line
View on ClinicalTrials.gov: NCT02919423 ↗Enrolled (actual)
31
Serious AEs
0.0%
Results posted
Feb 2019
Primary outcome: Primary: Change in Functional Connectivity Strength Measured With Functional Magnetic Resonance Imaging — .25; .13 correlation coefficient
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- transcranial magnetic stimulation (Device)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Duke University
- Primary completion
- Jan 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Functional Connectivity Strength Measured With Functional Magnetic Resonance Imaging |
.25; .13 | — |
Summary
The purpose of this study is to investigate the modulatory effects of repetitive transcranial magnetic stimulation (rTMS) on functional connectivity with the insula. Functional connectivity (FC) measures the interaction between brain regions, and recent neuroimaging studies have used FC to investigate how addiction affects FC among pertinent brain regions. rTMS, which can excite cortical neurons, has shown promise as a method to manipulate brain connectivity and could be used therapeutically to treat addiction. However, investigators first need more information on brain FC and how it relates to behavior, in order to guide rTMS target selection.
Eligibility Criteria
Inclusion Criteria
- generally healthy
- between the ages of 18-55
- right-handed
Exclusion Criteria
- significant health problems (e.g., current and uncontrolled liver, lung, or heart problems) or presence of medical illness likely to alter brain morphology (including history of seizure, history of epilepsy in self or first degree relatives, stroke, brain surgery, head injury, and known structural brain lesion)
- current diagnosis of Axis I psychiatric disorders (e.g., depression, anxiety disorder, schizophrenia)
- meet DSM-5 criteria for current substance use disorder other than nicotine
- use of psychoactive medications that would result in a positive urine drug screen
- Current use of medications known to lower the seizure threshold
- positive breath alcohol concentration
- presence of conditions that would make MRI unsafe (e.g., metal implants, pacemakers)
- among women, a positive urine pregnancy test
- vision that cannot be corrected to 20/40
Data sourced from ClinicalTrials.gov (NCT02919423). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.