Phase 4
Completed N=80
Effect of Ketamine on Analgesia Post-Cardiac Surgery
Pain, Postoperative
Source: ClinicalTrials.gov NCT02925858 ↗
Enrolled (actual)
80
Serious AEs
0.0%
Results posted
Sep 2019
Primary outcomePrimary: Quantity of Opioids Used in the First 48 Hours Postoperatively — 10.71; 11.14 mg of Dilaudid
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
Randomized, controlled, double-blind pilot study evaluating the effect of an intraoperative infusion of intravenous Ketamine on the quantity of opioid consumed postoperatively in coronary artery bypass surgery patients receiving a median sternotomy.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Quantity of Opioids Used in the First 48 Hours Postoperatively |
10.71; 11.14 | — |
| SECONDARY Quantity of Opioids Used |
6.5; 6.7 | — |
| SECONDARY Pain Scores (Visual Analog Scale) |
2; 2 | — |
| SECONDARY Postoperative Nausea and Vomiting |
3; 2 | — |
| SECONDARY Intensive Care Unit Length of Stay |
1; 2 | — |
| SECONDARY Hospital Length of Stay |
8; 7 | — |
| SECONDARY Time to Extubation |
539; 494 | — |
| SECONDARY Delirium |
11; 7 | — |
| SECONDARY Time to Mobilization |
32; 23 | — |
| SECONDARY Time to Ambulation |
63; 56 | — |
Eligibility Criteria
Inclusion Criteria
- Patients 18 years of age or older coming for coronary artery bypass surgery with a left ventricular ejection fraction over 50% and able to consent prior to surgery
Exclusion Criteria
- Minimally invasive cardiac surgery
- Preoperative opioid use
- Preoperative hepatic or renal dysfunction
Data sourced from ClinicalTrials.gov (NCT02925858). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.