Phase 4 N=80 Randomized Quadruple-blind Prevention

Effect of Ketamine on Analgesia Post-Cardiac Surgery

Pain, Postoperative

Bottom Line

View on ClinicalTrials.gov: NCT02925858 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Sep 2019

Primary outcome: Primary: Quantity of Opioids Used in the First 48 Hours Postoperatively — 10.71; 11.14 mg of Dilaudid

Study Design & Population

Study type: Interventional
Phase: Phase 4
Interventions: Normal Saline Flush, 0.9% Injectable Solution_#1 (Drug); Ketamine Hydrochloride (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Jewish General Hospital
Primary completion: Nov 2018

Outcome Measures

Outcome	Result	p-value
PRIMARY Quantity of Opioids Used in the First 48 Hours Postoperatively	10.71; 11.14	—
SECONDARY Quantity of Opioids Used	6.5; 6.7	—
SECONDARY Pain Scores (Visual Analog Scale)	2; 2	—
SECONDARY Postoperative Nausea and Vomiting	3; 2	—
SECONDARY Intensive Care Unit Length of Stay	1; 2	—
SECONDARY Hospital Length of Stay	8; 7	—
SECONDARY Time to Extubation	539; 494	—
SECONDARY Delirium	11; 7	—
SECONDARY Time to Mobilization	32; 23	—
SECONDARY Time to Ambulation	63; 56	—

Summary

Randomized, controlled, double-blind pilot study evaluating the effect of an intraoperative infusion of intravenous Ketamine on the quantity of opioid consumed postoperatively in coronary artery bypass surgery patients receiving a median sternotomy.

Eligibility Criteria

Inclusion Criteria

Patients 18 years of age or older coming for coronary artery bypass surgery with a left ventricular ejection fraction over 50% and able to consent prior to surgery

Exclusion Criteria

Minimally invasive cardiac surgery
Preoperative opioid use
Preoperative hepatic or renal dysfunction

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02925858). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.